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Alzheimers Dement
December 2024
Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Background: Cognitive decline associated with Alzheimer's disease (AD) correlates with hyperphosphorylated tau (pTau) propagating between neurons along networks connected by synapses. It has been hypothesized this transcellular transmission occurs partially by extracellular vesicles (EVs). Both genetic and pharmacological inhibition of nSMase2 has been found to inhibit EV biogenesis and pTau propagation.
View Article and Find Full Text PDFDementia Care Research and Psychosocial Factors.
Alzheimers Dement
December 2024
University of British Columbia - Okanagan campus, Kelowna, BC, Canada.
Background: Memory Café, introduced by Dr. Bere Miesen in 1997, has become a global initiative fostering connections among individuals affected by dementia. This community-based platform facilitates interactions between dementia patients, caregivers, professionals, and the wider public, allowing for open sharing of experiences.
View Article and Find Full Text PDFDementia Care Research and Psychosocial Factors.
Alzheimers Dement
December 2024
Otsuka America Pharmaceutical Inc., Princeton, NJ, USA.
Background: Language serves as a powerful tool in shaping perceptions and reinforcing societal norms. Current understanding suggests that the language used to describe dementia can impact how the condition is perceived, understood, and addressed within various cultural contexts. Further, language can play a pivot role in shaping caregiving practices, willingness to seek medical care, and the openness, or lack thereof, to speak about the condition.
View Article and Find Full Text PDFDementia Care Research and Psychosocial Factors.
Alzheimers Dement
December 2024
University of Michigan, Ann Arbor, MI, USA.
Background: Despite an increasing prevalence of Alzheimer's disease and related dementias among Black older adults, large disparities remain in early diagnosis, treatment, and support service referral. Further, services intended to support family caregivers are typically designed around older adult spousal caregivers with little consideration to the wide diversity of families affected by dementia. This qualitative descriptive study examined the caregiving experiences of Black relatives of persons with dementia with the aim of informing the development of more culturally responsive support programming.
View Article and Find Full Text PDFDementia Care Research and Psychosocial Factors.
Alzheimers Dement
December 2024
Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL, USA.
Background: Understanding social, behavioral, and environmental determinants of health (SBEDOH) are key in identifying modifiable risk factors for Alzheimer's Disease and related Dementias (ADRD), particularly the disproportionate burden seen in minorities. However, a lack of standardized SBEDOH methods exists with current methods limited in scope and cultural sensitivity (i.e.
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