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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6987296 | PMC |
| http://dx.doi.org/10.3389/fncir.2019.00084 | DOI Listing |
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Remotely induced electrical modulation of deep brain circuits in non-human primates.
Front Hum Neurosci
December 2024
Department of Biomedical Engineering, University of Utah, Salt Lake City, UT, United States.
Introduction: The combination of magnetic and focused ultrasonic fields generates focused electric fields at depth entirely noninvasively. This noninvasive method may find particularly important applications in targeted treatments of the deep brain circuits involved in mental and neurological disorders. Due to the novelty of this method, it is nonetheless unknown which parameters modulate neural activity effectively.
View Article and Find Full Text PDFSex differences in the relationships between 24-h rest-activity patterns and plasma markers of Alzheimer's disease pathology.
Alzheimers Res Ther
December 2024
Faculty of Health, Medicine and Life Sciences, Mental Health and Neuroscience Research Institute, Alzheimer Centre Limburg, Maastricht University, Maastricht, The Netherlands.
Background: Although separate lines of research indicated a moderating role of sex in both sleep-wake disruption and in the interindividual vulnerability to Alzheimer's disease (AD)-related processes, the quantification of sex differences in the interplay between sleep-wake dysregulation and AD pathology remains critically overlooked. Here, we examined sex-specific associations between circadian rest-activity patterns and AD-related pathophysiological processes across the adult lifespan.
Methods: Ninety-two cognitively unimpaired adults (mean age = 59.
Widespread neuroanatomical integration and distinct electrophysiological properties of glioma-innervating neurons.
Proc Natl Acad Sci U S A
December 2024
HHMI, Department of Neurobiology, Harvard Medical School, Boston, MA 02115.
Article Synopsis
- Gliomas are the most common malignant brain tumors, often leading to serious neurological issues and high mortality, yet they usually do not spread outside the brain, suggesting they depend on the brain's unique environment.* -
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The therapeutic potential of low-intensity focused ultrasound for treating substance use disorder.
Front Psychiatry
November 2024
Department of Chemistry, University of Virginia, Charlottesville, VA, United States.
Substance use disorder (SUD) is a persistent public health issue that necessitates the exploration of novel therapeutic interventions. Low-intensity focused ultrasound (LIFU) is a promising modality for precise and invasive modulation of brain activity, capable of redefining the landscape of SUD treatment. The review overviews effective LIFU neuromodulatory parameters and molecular mechanisms, focusing on the modulation of reward pathways in key brain regions in animal and human models.
View Article and Find Full Text PDFSomatosensory integration in robot-assisted motor restoration post-stroke.
Front Aging Neurosci
November 2024
Department of Biomedical Engineering, The Hong Kong Polytechnic University, Kowloon, Hong Kong SAR, China.
Disruption of somatosensorimotor integration (SMI) after stroke is a significant obstacle to achieving precise motor restoration. Integrating somatosensory input into motor relearning to reconstruct SMI is critical during stroke rehabilitation. However, current robotic approaches focus primarily on precise control of repetitive movements and rarely effectively engage and modulate somatosensory responses, which impedes motor rehabilitation that relies on SMI.
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