Background: This paper describes a new specific test to asses spatial and orientation abilities: Navigation Ability Test (NAT). The goal of this study was to determine if football players and normal subjects use vestibular information to keep track of their positions while walking through the Navigation Ability Test.
Methods: This study was conducted on a total of 120 patients undergoing Navigation Ability Test (NAT): 60 football players and 60 normal subjects were recruited on the basis of no history of vertigo/balance disorders and a negative otoneurological instrumental examination and the second group of the football players were recruited from Division B, Division Under-21 and Women's League. Patients who met the inclusion criteria were enrolled in the study.
Results: Our results showed differences between sexes during navigation tasks are not related to spatial learning per se, but appear to be the consequence of difference in ability to effectively use specific types of distal information such as room geometry. The NAT showed that the route-times walked with eyes closed are always longer than in normal people and mistakes improve with training.
Conclusions: These results show that NAT could suggest to the coach and trainers valuable information about the characteristics of the players and how they should play in the field. Although there are some intrinsic difficulties, for example in creating patient-specific versions of the test, preliminary normative data indicate that this original test is workable and provides important information in therapy rehabilitation for vestibular disorder.
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http://dx.doi.org/10.23736/S0022-4707.20.10110-5 | DOI Listing |
Innovation (Camb)
January 2025
AIM Center, College of Life Sciences and Technology, Beijing University of Chemical Technology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
Predicting free energy changes (ΔΔG) is essential for enhancing our understanding of protein evolution and plays a pivotal role in protein engineering and pharmaceutical development. While traditional methods offer valuable insights, they are often constrained by computational speed and reliance on biased training datasets. These constraints become particularly evident when aiming for accurate ΔΔG predictions across a diverse array of protein sequences.
View Article and Find Full Text PDFJ Mater Chem B
January 2025
Bio-Organic Chemistry, Departments of Biomedical Engineering and Chemical Engineering & Chemistry, Institute for Complex Molecular Systems, Eindhoven University of Technology, 5600 MB Eindhoven, The Netherlands.
Hybrid nano-sized motors with navigation and self-actuation capabilities have emerged as promising nanocarriers for a wide range of delivery, sensing, and diagnostic applications due to their unique ability to achieve controllable locomotion within a complex biological environment such as tissue. However, most current nanomotors typically operate using a single driving mode, whereas propulsion induced by both external and local stimuli could be more beneficial to achieve efficient motility in a biomedical setting. In this work, we present a hybrid nanomotor by functionalizing biodegradable stomatocytes with platinum nanoparticles (Pt NPs).
View Article and Find Full Text PDFBMC Public Health
January 2025
Health and Society, Department of Social Sciences, Wageningen University & Research, Hollandseweg 1, Wageningen, 6706KN, The Netherlands.
Background: A healthy diet during pregnancy is vital for the well-being of both mothers and babies. However, navigating dietary choices amidst the unique psychological and physiological changes of pregnancy can be challenging. Empowerment, defined as the ability to improve capacities, critically analyse situations, and take actions to improve them, can support pregnant women to make healthier choices.
View Article and Find Full Text PDFAnn Fam Med
January 2025
University of Saskatchewan, School of Rehabilitation Sciences, Saskatoon, Saskatchewan, Canada
Purpose: People who are transgender or gender diverse (PTGD) often experience difficulties navigating the health care system due to a variety of factors such as lack of knowledgeable and/or culturally competent clinicians, discrimination, and structural and/or socioeconomic barriers. We sought to determine whether a peer health navigator service in the Canadian province of Saskatchewan helped connect transgender and gender-diverse clients and health care practitioners (HCPs) to resources, and how this service changed their health care experiences.
Methods: Semistructured interviews were conducted with 9 clients and 9 HCPs.
Peptides play critical roles in cellular functions such as signaling and immune regulation, and peptide-based biotherapeutics show great promise for treating various diseases. Among these, cell-penetrating peptides (CPPs) are particularly valuable for drug delivery due to their ability to cross cell membranes. However, the mechanisms underlying CPP-mediated transport, especially across the blood-brain barrier (BBB), remain poorly understood.
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