AI Article Synopsis
- The study aimed to assess how effective stem cells are in repairing facial nerve injuries by analyzing various research articles about animal models.
- A total of 4,614 articles were found, with 15 ultimately included for a detailed analysis, revealing that stem cell treatment significantly improved vibrissae movement and reduced facial paralysis compared to controls.
- Findings showed that the group treated with stem cells had increased myelinated fiber density and thicker myelin sheaths, indicating a potential for enhancing facial nerve regeneration.
Article Abstract
Objective: To systematically evaluate the repairing effect of stem cells on facial nerve defects.
Methods: Articles regarding the regenerating effect of stem cells on facial nerves in animals were collected from the databases of Pubmed, Cochrane Library, Web of Science, Embase, Scopus, and CBM. Two professionals independently completed the article screening, data extraction, and bias risk assessment. RevMan 5.3 and random-effects models were used for the statistical analysis, and the results were presented in the form of mean differences (MD) with a 95%CI. The results of functional evaluation (vibrissae movement, facial paralysis) and histological evaluation (density of myelinated fibers, diameter of fibers, thickness of myelin sheath, G ratio) of facial nerve were Meta-analyzed.
Results: A total of 4 614 articles were retrieved from the 6 databases, and 15 of these articles were included in the Meta-analysis. For vibrissae movement and facial paralysis, the stem cell group scored significantly higher than the non-stem cell group (P<0.05). The density of myelinated fibers and thickness of the myelin sheath in the stem cell group were higher than those in the non-stem cell group (P<0.05). The G ratio in the stem cell group was smaller than that in the non-stem cell group (P=0.001). There was no significant difference in fiber diameter (P=0.08).
Conclusions: Stem cells have potential in promoting facial nerve regeneration.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184294 | PMC |
| http://dx.doi.org/10.7518/hxkq.2020.01.011 | DOI Listing |
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