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The utility of routine intraoperative CSF during ventricular shunt insertion: a 10-year retrospective cohort study.
J Neurosurg Pediatr
January 2025
1Department of Neurosurgery, Queensland Children's Hospital, Brisbane; and.
Objective: Ventricular shunt insertion is a common procedure in pediatric neurosurgical practice. In many areas of medicine there is a push toward rationalization of healthcare resources and a reduction in low-value tests or procedures. The intraoperative sampling of CSF at the time of shunt insertion is one traditional aspect of care that has not been rigorously evaluated.
View Article and Find Full Text PDFBeyond the Dailey-Townes Model: Chemical Information from the Electric Field Gradient.
J Phys Chem A
January 2025
Laboratoire de Chimie et Physique Quantique, UMR 5626 CNRS - Université Toulouse III-Paul Sabatier, 118 Route de Narbonne, F-31062 Toulouse, France.
In this work, we reexamine the Dailey-Townes model by systematically investigating the electric field gradient (EFG) in various chlorine compounds, dihalogens, and the uranyl ion (). Through the use of relativistic molecular calculations and projection analysis, we decompose the EFG expectation value in terms of atomic reference orbitals. We show how the Dailey-Townes model can be seen as an approximation to our projection analysis.
View Article and Find Full Text PDFQuantitative Assessment of the Effect of Chronic Kidney Disease on Plasma P-Tau217 Concentrations.
Neurology
February 2025
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.
Background And Objectives: Chronic kidney disease (CKD) is known to be associated with increased plasma phosphorylated tau217 (p-tau217) concentrations, potentially confounding the utility of plasma p-tau217 measurements as a marker of amyloid pathology in individuals with suspected Alzheimer disease (AD). In this study, we quantitatively investigate the relationship of plasma p-tau217 concentrations vs estimated glomerular filtration rate (eGFR) in individuals with CKD with and without amyloid pathology.
Methods: This was a retrospective examination of data from 2 observational cohorts from either the Mayo Clinic Study of Aging or the Alzheimer's Disease Research Center cohorts.
In the current cybersecurity landscape, Distributed Denial of Service (DDoS) attacks have become a prevalent form of cybercrime. These attacks are relatively easy to execute but can cause significant disruption and damage to targeted systems and networks. Generally, attackers perform it to make reprisal but sometimes this issue can be authentic also.
View Article and Find Full Text PDFCharacteristics of ChatGPT users from Germany: Implications for the digital divide from web tracking data.
PLoS One
January 2025
Department of Computer and Information Science, Konstanz University, Konstanz, Baden-Württemberg, Germany.
A major challenge of our time is reducing disparities in access to and effective use of digital technologies, with recent discussions highlighting the role of AI in exacerbating the digital divide. We examine user characteristics that predict usage of the AI-powered conversational agent ChatGPT. We combine behavioral and survey data in a web tracked sample of N = 1376 German citizens to investigate differences in ChatGPT activity (usage, visits, and adoption) during the first 11 months from the launch of the service (November 30, 2022).
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