With the recent passing away of Emeritus Professor Sally (Sarah) E. Smith, the mycorrhiza research community has lost one of its most outstanding members. Sally's contribution to knowledge in the fields of soil microbiology and root physiology will continue to be an inspiration to present and future scientists.
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DNA Methylation Signatures of Cardiovascular Health Provide Insights into Diseases.
medRxiv
November 2024
Nutrition Epidemiology and Data Science, Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA.
Background: The association of overall cardiovascular health (CVH) with changes in DNA methylation (DNAm) has not been well characterized.
Methods: We calculated the American Heart Association's Life's Essential 8 (LE8) score to reflect CVH in five cohorts with diverse ancestry backgrounds. Epigenome-wide association studies (EWAS) for LE8 score were conducted, followed by bioinformatic analyses.
Thermophilic Behavior of Heat-Dissociative Coacervate Droplets.
Nano Lett
December 2024
Materials Science and Engineering Program, Texas Materials Institute, The University of Texas at Austin, Austin, Texas 78712, United States.
In exploring the genesis of life, liquid-liquid phase-separated coacervate droplets have been proposed as primitive protocells. Within the hydrothermal hypothesis, these droplets would emerge from molecule-rich hot fluids and thus be subjected to temperature gradients. Investigating their thermophoretic behavior can provide insights into protocell footprints in thermal landscapes, advancing our understanding of life's origins.
View Article and Find Full Text PDFAutocatalytic DNA circuitries.
Chem Soc Rev
November 2024
Department of Chemistry, Center for Bioanalytical Chemistry, Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Tsinghua University, Beijing 100084, China.
Article Synopsis
- * Recent advances focus on constructing these DNA circuits using biocatalysis and dynamic hybridization methods, enabling ultra-sensitive detection of important biological molecules like DNA, RNA, and proteins.
- * The review covers practical uses, challenges, and future directions of autocatalytic DNA circuits, emphasizing their role in bioanalysis and biomedical applications, as well as potential development into intricate DNA nanostructures.
Metagenomic Study of the MESA: Detection of and Association With Coronary Heart Disease.
J Am Heart Assoc
October 2024
Division of Cardiology, Department of Medicine University of California Irvine Irvine CA.
Background: Inflammation is a feature of coronary heart disease (CHD), but the role of proinflammatory microbial infection in CHD remains understudied.
Methods And Results: CHD was defined in the MESA (Multi-Ethnic Study of Atherosclerosis) as myocardial infarction (251 participants), resuscitated arrest (2 participants), and CHD death (80 participants). We analyzed sequencing reads from 4421 MESA participants in the National Heart, Lung, and Blood Institute Trans-Omics for Precision Medicine program using the PathSeq workflow of the Genome Analysis Tool Kit and a 65-gigabase microbial reference.
From the ground up: stakeholders' representations of the Irish longitudinal study on ageing (TILDA).
Psychol Health Med
October 2024
School of Medicine, Digital healthcare ethics laboratory (Digit-HeaL), Catholic University of Croatia, Zagreb, Croatia.
Article Synopsis
- Healthy ageing is important for older people and can be helped by how society supports them, but this support can sometimes be lacking.
- The TILDA project studies how to promote healthy ageing and finds out what older people and their support groups think about its efforts.
- Interviews with 15 organizations showed some limitations of TILDA, like not being inclusive enough, but also highlighted its benefits, like providing useful information to help plan for the needs of older people in the future.
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