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miR-542-3p/PIK3R1 axis is involved in hsa_circ_0087104-mediated inhibition of esophageal squamous cell carcinoma metastasis.
Am J Cancer Res
December 2024
Department of Breast Surgery, The First Affiliated Hospital, College of Medicine, Zhejiang University Hangzhou 310003, Zhejiang, China.
Esophageal squamous cell carcinoma (ESCC), the most predominant subtype of esophageal cancer, is notorious for its high lymph node metastatic potential and poor prognosis. Growing evidence has demonstrated crucial function of circRNAs in human malignancies. However, the knowledge of circRNAs in lymph node metastasis of ESCC is still inadequate.
View Article and Find Full Text PDFDeletion of AMP-activated protein kinase impairs metastasis and is rescued by ROS scavenging or ectopic CD36 expression.
Cell Rep
January 2025
Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL 60607, USA; Research and Development Section, Jesse Brown VA Medical Center, Chicago, IL 60612, USA. Electronic address:
AMPK's role in tumor initiation and progression is controversial. Here, we provide genetic evidence that AMPK is required for metastasis in mouse models of breast cancer. In a mouse model of spontaneous breast cancer metastasis, the deletion of AMPK before and after tumor onset decreased breast cancer metastasis, and similar results were obtained after AMPK deletion in breast cancer cell lines.
View Article and Find Full Text PDFHow does the knowledge level of physicians and nurses working at primary health centers affect their preference for oral contraceptives in an inland Turkish province?
BMC Prim Care
January 2025
School of Medicine, Department of Obstetrics and Gynecology, Afyonkarahisar Health Sciences University, Zafer Sağlık Külliyesi Dörtyol Mahallesi 2078 Sokak No: 3, Afyonkarahisar, Turkey.
Background: Standardizing the knowledge of health care givers and eliminating their misconceptions would help to achieve optimal service for contraception. This study aims to evaluate the knowledge levels of physicians and nurses working at primary health care centers about the oral contraceptive pill (OCP) use.
Methods: This is a cross-sectional review of 306 professional care givers (117 physicians and 189 nurses) who are working at primary health care centers.
Identification of Tumor-Suppressive Controlled Genes: as a Therapeutic Target in Breast Cancer.
Noncoding RNA
November 2024
Department of Functional Genomics, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan.
Our recently created RNA-sequence-based microRNA (miRNA) expression signature in breast cancer clinical specimens revealed that some family members were significantly downregulated in cancer tissues. Based on TCGA database analyses, we observed that among the family members, (the passenger strand derived from pre-) was significantly downregulated in breast cancer (BC) clinical specimens, and its low expression predicted worse prognoses. Ectopic expression assays showed that transfected cancer cells (MDA-MB-157 and MDA-MB-231) had their aggressive phenotypes significantly suppressed, e.
View Article and Find Full Text PDFDEVELOPMENT OF ENDOSALPINGIOSIS IN PATIENTS WITH A HISTORY OF BREAST CANCER.
Georgian Med News
October 2024
1Department of Obstetrics and Gynecology, National Hospital Organization Kyoto Medical Center, Kyoto city, Kyoto; 3Seeds Development and Research Platform Project, Japan Agency for Medical Research and Development (AMED), Chiyoda-ku, Tokyo; 4Kyoto University Graduate School of Medicine, Kyoto city, Kyoto, Japan.
Endosalpingiosis occurs in relatively young women. The incidence of endosalpingiosis exceeds that of other diseases affecting female tissues. As endosalpingiosis is a benign tumor, several women with endosalpingiosis are asymptomatic.
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