Genome Composition and Divergence of the Novel Coronavirus (2019-nCoV) Originating in China.

Cell Host Microbe

Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China; Suzhou Institute of Systems Medicine, Suzhou, Jiangsu 215123, China. Electronic address:

Published: March 2020

AI Article Synopsis

  • A detailed study of the 2019-nCoV genome has shown notable differences from SARS and other similar coronaviruses.
  • Researchers found 380 specific amino acid changes that distinguish 2019-nCoV from these related viruses.
  • These differences may have led to unique functional and disease-causing characteristics in 2019-nCoV.

Article Abstract

An in-depth annotation of the newly discovered coronavirus (2019-nCoV) genome has revealed differences between 2019-nCoV and severe acute respiratory syndrome (SARS) or SARS-like coronaviruses. A systematic comparison identified 380 amino acid substitutions between these coronaviruses, which may have caused functional and pathogenic divergence of 2019-nCoV.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7154514PMC
http://dx.doi.org/10.1016/j.chom.2020.02.001DOI Listing

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