Unlabelled: Pairwise sequence covariations are a signal of conserved RNA secondary structure. We describe a method for distinguishing when lack of covariation signal can be taken as evidence against a conserved RNA structure, as opposed to when a sequence alignment merely has insufficient variation to detect covariations. We find that alignments for several long non-coding RNAs previously shown to lack covariation support do have adequate covariation detection power, providing additional evidence against their proposed conserved structures.
Availability And Implementation: The R-scape web server is at eddylab.org/R-scape, with a link to download the source code.
Supplementary Information: Supplementary data are available at Bioinformatics online.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214042 | PMC |
| http://dx.doi.org/10.1093/bioinformatics/btaa080 | DOI Listing |
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