Despite the fact that HIV- and AIDS-related stigma is consistently identified as an impediment to HIV prevention, a multilevel conceptualisation of HIV- and AIDS-related stigma continues to be poorly understood. The role of multilevel HIV- and AIDS-related stigma in the HIV prevention and intervention behaviours of Asian American and Pacific Islander who have sex with men in the USA is particularly overlooked. Psychology has contributed significantly to the identification of individual or interpersonal level factors influencing HIV- and AIDS-related stigma, while sociology has contributed to a more societal perspective. This dichotomy has led to the absence of a multilevel conceptual framework for analysing the HIV- or AIDS-related stigma experienced by Asian American and Pacific Islander who have sex with men in the USA. In this paper, we argue for need to develop such a model which is culturally grounded and bridges the individual, interpersonal and societal conceptualisations of stigma prominent in the social science literature. To that end, we use Bronfenbrenner's ecological systems theory to explore the manifestation of HIV stigma at the micro, meso and macro levels and how these might impact on HIV testing and HIV service utilisation among Asian American and Pacific Islander men who have sex with men. We conclude by identifying some practice and research implications.
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http://dx.doi.org/10.1080/13691058.2019.1690164 | DOI Listing |
BMC Public Health
January 2025
Department of Public Health, Woldia University, Woldia, Ethiopia.
Background: Despite advancements in Human Immunodeficiency Virus (HIV) treatment and care, undernutrition remains a significant concern, accelerating disease progression and risk of Acquired Immune Deficiency Syndrome (AIDS)-related deaths. The nutritional status of second-line antiretroviral treatment (SLART) users in Ethiopia has not been thoroughly investigated. So, this study aimed to assess the nutritional status of HIV/AIDS patients who were on SLART and its associated factors in Northern Ethiopia.
View Article and Find Full Text PDFMed Mycol
January 2025
Division of Infectious Diseases, Department of Medicine, University of Minnesota, Minneapolis, MN, USA.
Given extensive improvements in access to antiretroviral therapy (ART) over the past 12 years, the HIV and cryptococcal meningitis landscapes have dramatically changed since 2010. We sought to evaluate changes in clinical presentation and clinical outcomes of people presenting with HIV-associated cryptococcal meningitis between 2010 and 2022 in Uganda. We analyzed three prospective cohorts of HIV-infected Ugandans with cryptococcal meningitis during 2010-2012, 2013-2017, and 2018-2022.
View Article and Find Full Text PDFCurr Opin HIV AIDS
December 2024
Department of Microbial Infection and Immunity, College of Medicine, The Ohio State University, Columbus, Ohio.
Purpose Of Review: Despite decades of insights about the role of natural killer (NK) cells in HIV infection, their persistent dysregulation despite antiretroviral therapy (ART) and its pathological consequences have been incompletely delineated. In this review, we highlight recent findings on the immunophenotypic and functional alterations of NK cells during virally suppressed HIV infection and explore their potential impact on promoting non-AIDS related comorbidities among people living with HIV (PLWH).
Recent Findings: Of note are the apparent persistent activated profiles of NK cells and pathophysiological events such as endoplasmic reticulum (ER) stress in potentially driving NK cell derived inflammation and tissue destruction.
Pathogens
November 2024
Department of Tropical Medicine, Bernhard Nocht Institute for Tropical Medicine & I. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20359 Hamburg, Germany.
Although the etiological relevance of the detection of microsporidia in human stool samples remains uncertain, the immunological status of patients has been posited as an important determinant of potential clinical impact of these parasites. To further assess the interplay between the epidemiology of microsporidia and immunological markers, we conducted a study utilizing real-time PCR targeting , , , and , combined in a single fluorescence channel. The study involved a cohort of 595 clinically and immunologically well-characterized Ghanaian HIV patients, alongside 82 HIV-negative control individuals from Ghana.
View Article and Find Full Text PDFPurpose Pre-clinical studies have demonstrated direct influences of the autonomic nervous system (ANS) on the immune system. However, it remains unknown if connections between the peripheral ANS and immune system exist in humans and contribute to the development of chronic inflammatory disease. This study had three aims: 1.
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