AI Article Synopsis
- NUT midline carcinoma is a rare, aggressive cancer characterized by a genetic rearrangement of the NUT gene, typically fused with the BRD4 gene, which impacts its diagnosis and treatment.
- First identified in 1991, this carcinoma often manifests in the mediastinum or head and neck, with a median survival rate of only 7 months due to ineffective treatment options.
- A case report of a 44-year-old male with symptoms like headache and dizziness highlights the importance of recognizing this rare cancer in adults and emphasizes the need for differentiation from other similar tumors.
Article Abstract
Nuclear protein in testis (NUT) midline carcinoma is poorly differentiated carcinoma defined by rearrangement of NUT gene on 15 to other genes, usually BRD4 on 19. It is first described in 1991. These tumors are most commonly seen in the mediastinum and 35% occur in head and neck. It is a highly aggressive tumor with a median survival of 7 months because of ineffective chemotherapy and undefined treatment. Hence, we must differentiate these tumors from other poorly differentiated tumors. Here, we present a case of NUT midline carcinoma of 44-year male, who presented with headache and dizziness, confirmed by immunohistochemistry of NUT antibody. The aim of this case report is to increase the awareness about this entity in adults with brief review of relevant literature.
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| http://dx.doi.org/10.4103/IJPM.IJPM_373_19 | DOI Listing |
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