AI Article Synopsis
- A new method has been created for the nucleophilic γ-phenylation and γ-alkylation of α,β-unsaturated amides.
- This reaction involves introducing phenyl and alkyl groups to a vinylketene N,O-acetal, which is produced directly from an α,β-unsaturated N-alkoxyamide.
- The process consists of two steps but is conducted in a single pot by cleaving the N-O bond.
Article Abstract
The nucleophilic γ-phenylation and γ-alkylation of α,β-unsaturated amides have been developed. This umpolung reaction allows the regioselective introduction of phenyl and alkyl groups to a vinylketene N,O-acetal, which is generated in situ from an α,β-unsaturated N-alkoxyamide, followed by N-O bond cleavage in a two-step, one-pot process.
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| http://dx.doi.org/10.1039/d0ob00125b | DOI Listing |
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