AI Article Synopsis
- PARPs, originally recognized for their role in DNA repair, also function in regulating metabolism, affecting how the body manages carbohydrates and lipids.
- PARP1 and PARP2 are key players in the development of fat cells and influence the types of fat (white, brown, beige) stored in the body, which impacts energy balance.
- Research suggests that the effects of PARPs on metabolism and obesity are relevant to humans, as demonstrated by genetic studies involving identical twins and variations in PARP activity.
Article Abstract
Poly(ADP-ribose) polymerases (PARPs or ARTDs), originally described as DNA repair factors, have metabolic regulatory roles. PARP1, PARP2, PARP7, PARP10, and PARP14 regulate central and peripheral carbohydrate and lipid metabolism and often channel pathological disruptive metabolic signals. PARP1 and PARP2 are crucial for adipocyte differentiation, including the commitment toward white, brown, or beige adipose tissue lineages, as well as the regulation of lipid accumulation. Through regulating adipocyte function and organismal energy balance, PARPs play a role in obesity and the consequences of obesity. These findings can be translated into humans, as evidenced by studies on identical twins and SNPs affecting PARP activity.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7050491 | PMC |
| http://dx.doi.org/10.1101/gad.334284.119 | DOI Listing |
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