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Oxidative metabolism of typical phenolic compounds of Danshen by electrochemistry coupled to quadrupole time-of-flight tandem mass spectrometry. | LitMetric

AI Article Synopsis

  • This study utilized electrochemistry combined with online quadrupole time-of-flight tandem mass spectrometry (EC/Q-TOF/MS) to explore the oxidative transformation pathways of five phenolic acids found in Danshen.
  • The researchers simulated phase I oxidative metabolism in an electrochemical reactor and examined how the resulting products reacted with biomolecules, specifically glutathione, through covalent adduct formation.
  • The findings revealed that the metabolites produced electrochemically closely matched those observed in traditional in vivo studies, suggesting EC/Q-TOF/MS is an effective method for predicting the metabolic transformations of functional foods.

Article Abstract

An electrochemistry coupled to online quadrupole time-of-flight tandem mass spectrometry (EC/Q-TOF/MS) was applied to investigate the oxidative transformation and metabolic pathway of five phenolic acids in Danshen sample. Simulation of the phase I oxidative metabolism was carried out in an electrochemical reactor equipped with a glassy carbon working electrode. The phase II reactivity of the generated oxidative products towards biomolecules (such as glutathione) was investigated by ways of covalent adduct formation experiments. The results obtained by EC/MS were compared with well-known in vitro studies by conducting rat liver microsome incubations. Structures of the electrochemically produced metabolites were identified by accurate mass measurement and previously results in vivo metabolites. It was indicated that the electrochemical oxidation was in good accordance with similar products found in vivo experiments. In conclusion, this work confirmed that EC/Q-TOF/MS was a promising analytical tool in the prediction of metabolic transformations of functional foods.

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Source
http://dx.doi.org/10.1016/j.foodchem.2020.126270DOI Listing

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