Objective: The aim of this study was to investigate the effects of adverse childhood experiences and life events on the inhibitory control ability, cognitive flexibility, and working memory of college students.
Methods: The study involved testing the participants using the Adverse Childhood Experiences (ACEs) Questionnaire, the Adolescent Life Events Scale (Adolescent Self-rating Life Events Checklist, ASLEC), and the program of executive functions designed by E-prime software.
Results: The incidence rate of ACEs was 44.8%. ACEs, life events, and inhibition ability were found to have a significant correlation (r1 = 0.50, r1 = 0.47, p < 0.01). In the switching task, the reaction time of the ACEs group was longer than the reaction time of the non-ACEs group (t = - 2.55, p < 0.05). Low scorers in the ASLEC exhibited lesser reaction times than their high-scoring counterparts in the tasks related to inhibition, switching, and working memory experiments. The regression analysis results showed that ACEs and life events had a possibility rate of 56% in predicting inhibition ability.
Conclusions: The incidence of ACEs was found to be high, and cognitive flexibility is significantly influenced by ACEs. Life events have a significant impact on inhibition ability, cognitive flexibility, and working memory. ACEs and life events were found to be reliable predictors of inhibition ability.
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http://dx.doi.org/10.1186/s41155-018-0107-y | DOI Listing |
Allergy Asthma Proc
January 2025
Department of Pharmacovigilance, Pharmacovigilance and Quality Assurance Group, Torii Pharmaceutical Co., Ltd., Tokyo, Japan.
Standardized quality (SQ) house-dust mite (HDM) sublingual immunotherapy tablets (10,000 Japanese allergy units [JAU], equivalent to 6 SQ-HDM in Europe and the United States) are licensed for the treatment of HDM-induced allergic rhinitis (AR) without age restriction, based on 52-week administration clinical trials. There are no large-scale data on the administration of 10,000 JAU for > 1 year in actual clinical practice. To examine the safety and effectiveness of 10,000 JAU during use for up to 3 years at real-world clinical sites in Japan.
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January 2025
From the Section of Allergy, Asthma and Immunology, Medicine and Pediatrics, Pennsylvania State University School of Medicine, Hershey, Pennsylvania and.
Patients with mast cell activation syndrome (MCAS) can be refractory to standard antimediator therapy. Alternative treatment options to reduce disease burden and improve quality of life are needed. To compile the evidence that supports the use of omalizumab for patients with refractory MCAS.
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December 2024
Oncology Department, Guang'anmen Hospital, China, Academy of Chinese Medical Sciences, Beixian Pavilion, No.5, Xicheng District, Beijing, China.
Background: The treatment of advanced colorectal cancer (CRC) has progressed slowly, with chemotherapy combined with targeted therapy being the first-line treatment for the disease, but the improvement in efficacy is not satisfactory. Compound Kushen injection (CKI) is one of the representative drugs of anti-cancer Chinese herbal injection drugs, which has been widely used in the adjunct treatment of cancer in China. The aim of this trial is to evaluate the efficacy and safety of CKI combined with first-line treatment of advanced CRC.
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December 2024
Institute for Musculoskeletal Health, Sydney Local Health District, Sydney, New South Wales, Australia.
Introduction: Sciatica is a debilitating condition that often becomes chronic, and for which there are few effective treatment options. Treatments such as the anti-depressant duloxetine have shown promise, but the evidence is inconclusive. We are describing a high quality, definitive trial to investigate the efficacy, safety and cost-effectiveness of duloxetine in chronic sciatica.
View Article and Find Full Text PDFIn Vivo
December 2024
School of Pharmacy, Hyogo Medical University, Kobe, Japan;
Background/aim: Nintedanib may cause adverse events such as elevated liver enzyme levels, diarrhea, and decreased appetite. These adverse events should be managed appropriately as they affect the quality of life of patients. This study has aimed to analyze patient characteristics and time-to-onset of adverse events caused by nintedanib using the Japanese Adverse Drug Event Report (JADER) database.
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