Utilization, effectiveness, and safety of tranexamic acid use in hip fracture surgery: A population-based study.

Objective: To assess the effect of tranexamic acid (TXA) use in hip fracture surgery.

Methods: A retrospective cohort study was performed using the Premier Healthcare database. A propensity score matching approach was applied to assess associations between TXA use and blood transfusion, perioperative complications, length of stay (LOS), and hospitalization cost.

Results: In 153,169 patients, TXA use was associated with a 17% decrease in odds of blood transfusion, no increase in the risk of perioperative complications, 16% shorter LOS, and minimal effects on hospitalization cost.

Conclusion: Our results are in support of a wider use of TXA in hip fracture surgery.

Level Of Evidence: Level III.