AI Article Synopsis
- Wischnewski spots, dark-brown-colored spots in the gastric mucosa, are often seen in hypothermia patients, but their formation mechanisms are unclear.
- Research indicates that hypothermia may trigger gastric acid and pepsin secretion, as experiments showed that cold temperatures increase the mRNA expression of gastrin and enhance the activity of the H,K-ATPase pump.
- These changes lead to increased acidity and pepsin levels in the stomach, which may cause small hemorrhages in the gastric mucosa, resulting in the appearance of Wischnewski spots during fatal hypothermia.
Article Abstract
Numerous dark-brown-coloured small spots called "Wischnewski spots" are often observed in the gastric mucosa in the patients dying of hypothermia, but the molecular mechanisms through which they develop remain unclear. We hypothesised that hypothermia may activate the secretion of gastric acid and pepsin, leading to the development of the spots. To investigate this, we performed experiments using organotypic rat gastric tissue slices cultured at 37 °C (control) or 32 °C (cold). Cold loading for 6 h lowered the extracellular pH in the culture medium. The mRNA expression of gastrin, which regulates gastric acid secretion, increased after cold loading for 3 h. Cold loading increased the expression of gastric H,K-ATPase pump protein in the apical canalicular membrane and resulted in dynamic morphological changes in parietal cells. Cold loading resulted in an increased abundance of pepsin C protein and an elevated mRNA expression of its precursor progastricsin. Collectively, our findings clarified that cold stress induces acidification by activating gastric H,K-ATPase pumps and promoting pepsin C release through inducing progastricsin expression on the gastric mucosa, leading to tiny haemorrhages or erosions of the gastric mucosa that manifest as Wischnewski spots in fatal hypothermia.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7002760 | PMC |
| http://dx.doi.org/10.1038/s41598-020-58894-8 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
An active protein from Dendrobium officinale residue: Protects the gastric mucosa and stabilized in the gastrointestinal tract.
Int J Biol Macromol
January 2025
Changchun University of Chinese Medicine, Key Laboratory of Ginseng Efficacy Substance Base and Biological Mechanism Research, Ministry of Education, Changchun 130117, China; Northeast Asia Research Institute of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun 130117, China. Electronic address:
A large number of by-products generated in the food industry is discarded as waste, especially the residue left after extracting plant resources, which is typically repurposed as fertilizer. In this study, we extracted and purified a new protein, DOP1, from the residue of Dendrobium officinale Kimura & Migo (D. officinale), and explored the protective effect of DOP1 on alcohol-induced gastric mucosal injury.
View Article and Find Full Text PDFCase report: Dieulafoy's lesion as a rare cause of massive gastrointestinal hemorrhage.
Int J Surg Case Rep
December 2024
General Surgery Department, Mahmoud El Matri Hospital, V59M+628, Ariana, Tunisia; Faculty of Medicine of Tunis, University of Tunis El Manar, R534+F9H, Rue de la Faculté de Médecine, Tunis, Tunisia.
Introduction And Importance: Dieulafoy's lesion is a rare but serious cause of gastrointestinal bleeding, typically affecting older adults. It involves an aberrant arteriole eroding the gastric mucosa, resulting in severe, recurrent bleeding that poses diagnostic and management challenges. We present a case report of massive gastrointestinal hemorrhage with hemodynamic instability associated with a Dieulafoy's lesion.
View Article and Find Full Text PDFGastric habronematidosis in mules: Gastroscopy and histopathology-based diagnosis.
Res Vet Sci
December 2024
Equine Medicine and Surgery Research Line (LIMCE), CENTAURO Research Group, School of Veterinary Medicine, Faculty of Agricultural Sciences, Universidad de Antioquia, Medellín 050010, Antioquia, Colombia.
This cross-sectional study aimed to describe the presence of gastric habronematidosis using gastroscopy and histopathology as diagnostic methods, in addition to evaluating the relationship between the parasite presence and concurrent gastric diseases. Numerous studies have been carried out with equines, mules not being targeted even though these are representative species because of number and the various agricultural tasks they perform worldwide. To fill this gap in the literature, this study evaluated a population of 97 male and female mules over two years old using two diagnostic methods.
View Article and Find Full Text PDFXiaohuafuning tang intervenes liver-depression-and-spleen-deficiency syndrome chronic-atrophic-gastritis by reshaping amino acid metabolism through gut Microbiota.
Phytomedicine
December 2024
Institue of Pharmaceutical Department, The First Affiliated Hospital of Anhui University of Traditional Chinese Medicine, No 117, Meishan Road, Hefei 230031, Anhui, PR China. Electronic address:
Background: Xiaohua Funing Tang (XHFND) is a decoction formula of traditional Chinese medicine (TCM) and possesses the potential to manage chronic atrophic gastritis (CAG) with liver depression and spleen deficiency (LDSD), but the mechanisms were still unclear.
Purpose: Our aim is to reveal the overall synergistic mechanisms of XHFND against CAG with LDSD.
Methods: Based on a CAG rat model with LDSD, this study combined metabolomics, gut microbiota, and network pharmacology techniques to demonstrate the XHFND mechanisms with multiple components and targets.
Differential expression of the ubiquitin-editing enzyme A20 in gastric biopsies indicates the severity of disease.
Histochem Cell Biol
December 2024
Institute of Pathology, Klinikum Bayreuth, 95445, Bayreuth, Germany.
A20, an ubiquitin-editing enzyme, plays a pivotal role in regulating cell signaling and immune responses. Dysregulated A20 expression has been associated with various pathological conditions, including inflammatory diseases and malignancies, where its expression levels often correlate with differing prognoses in solid tumors. This study aimed to explore the expression and cellular localization of A20 in both nonpathological and diseased human gastric tissues to gain deeper insights into its involvement in gastric pathologies.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!