Gut microbiota and neuroinflammation in pathogenesis of hypertension: A potential role for hydrogen sulfide.

Inflammation and gut dysbiosis are hallmarks of hypertension (HTN). Hydrogen sulfide (HS) is an important freely diffusing molecule that modulates the function of neural, cardiovascular and immune systems, and circulating levels of HS are reduced in animals and humans with HTN. While most research to date has focused on H₂S produced endogenously by the host, HS is also produced by the gut bacteria and may affect the host homeostasis. Here, we review an association between neuroinflammation and gut dysbiosis in HTN, with special emphasis on a potential role of HS in this interplay.