Although otomycosis is a disease spread throughout the world, there are only a few of studies about it. We aimed to evaluate the clinical efficacy of terbinafine hydrochloride spray (THS) in combination with 3% boric acid alcohol (3% BAA) ear drops compared to 3% BAA ear drops in otomycosis. This was a randomised, parallel-group, double-blind study involving 320 patients of both sexes aged 18 years or older. The clinical cure rate was higher ( = .01) with THS in combination with 3% BAA ear drops than with 3% BAA ear drops alone. The change of mean total symptom score was significant with THS in combination with 3% BAA ear drops ( = .035). No differences were found in the percentage of patients reporting resolution of otalgia between patients receiving THS in combination with 3% BAA ear drops and those receiving only 3% BAA ear drops. Resolution rates of pruritus, otorrhea, aural fullness, tinnitus and hypoacusis ( .005, = .004, = .002, = .001, = .004, respectively) was higher with THS in combination with 3% BAA ear drops, as was eradication ( = .001). There were seven mild adverse events, three with the THS in combination with 3% BAA ear drops (not related to the treatment) and four when 3% BAA was administered alone (not related to the treatment). THS in combination with 3% BAA ear drops is a more effective treatment for otomycosis than 3% BAA ear drops alone. The THS in combination with 3% BAA ear drops also has an excellent safety profile. To provides a safe and effective method for treating otomycosis.
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| http://dx.doi.org/10.1080/00016489.2020.1712474 | DOI Listing |
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