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Maternal weight affects placental DNA methylation of genes involved in metabolic pathways in the common marmoset monkey (Callithrix jacchus). | LitMetric
Research indicates that irregularities in placental DNA methylation could link a mother's weight during pregnancy to metabolic outcomes for the child.
A study using the common marmoset examined how maternal weight affects DNA methylation in placentas, revealing a focus on the relationship between maternal condition and metabolic programming.
The findings identified 74 genes related to maternal weight, many of which play key roles in energy metabolism and the regulation of metabolic pathways like glycolysis and lipid processing.
Article Abstract
Accumulating evidence suggests that dysregulation of placental DNA methylation (DNAm) is a mechanism linking maternal weight during pregnancy to metabolic programming outcomes. The common marmoset, Callithrix jaccus, is a platyrrhine primate species that has provided much insight into studies of the primate placenta, maternal condition, and metabolic programming, yet the relationships between maternal weight and placental DNAm are unknown. Here, we report genome-wide DNAm from term marmoset placentas using reduced representation bisulfite sequencing. We identified 74 genes whose DNAm pattern is associated with maternal weight during gestation. These genes are predominantly involved in energy metabolism and homeostasis, including the regulation of glycolytic and lipid metabolic processes pathways.
