AI Article Synopsis
- - The study focused on the antioxidant peptide LWHTH, derived from peptic hydrolysate, to explore its potential as a health-promoting food with antihypertensive properties.
- - LWHTH was found to inhibit angiotensin I-converting enzyme (ACE), a target for blood pressure regulation, with a significant effect observed at a concentration of 16.42 µM and maintained stability during gastrointestinal simulations.
- - Animal tests showed that LWHTH significantly lowered blood pressure in hypertensive rats, suggesting that it may be beneficial for human health as a functional food.
Article Abstract
This study investigated the antihypertensive effects of an antioxidant peptide, Leu-Trp-His-Thr-His (LWHTH), purified from peptic hydrolysate, to assess the bioactivity of the peptide and verify the value of as a health-promoting food. Also, the study presented structural evidence for the effects of LWHTH. The inhibitory effect of LWHTH on angiotensin I-converting enzyme (ACE) was assessed using enzyme reaction methods and the simulation methods in computational space. LWHTH inhibited ACE with an IC value of 16.42 ± 0.45 M. The LWHTH structure was stable, and its ACE inhibitory effect was retained under simulated gastrointestinal conditions. simulations revealed that LWHTH binds the active site of ACE, with residues LW making the ACE-LWHTH complex stable and residues HTH making the complex strong. Furthermore, LWHTH significantly reduced blood pressure in spontaneously hypertensive rats. These results demonstrate that LWHTH has the potential to be a healthy functional food with antihypertensive effects. Therefore, consumption may be beneficial for human health.
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| http://dx.doi.org/10.1089/jmf.2019.4415 | DOI Listing |
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