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Inhalable dry powders of rifampicin highlighting potential and drawbacks in formulation development for experimental tuberculosis aerosol therapy. | LitMetric

AI Article Synopsis

  • * The focus of this work is a literature review on inhalable dry powder formulations of rifampicin for treating tuberculosis, particularly emphasizing aerosol performance for pulmonary delivery.
  • * Despite various formulation strategies being researched, no candidate has advanced to commercial clinical testing yet, possibly due to inadequate models for evaluating their efficacy, therapeutic benefits, and cost-effectiveness.

Article Abstract

: Recently, tuberculosis was reported as the leading cause of death from a single infectious agent. Standard therapy includes administration of four first-line antibiotics, i.e. rifampicin, isoniazid, ethambutol, and pyrazinamide over a period of at least 26 weeks, which in case of rifampicin oftentimes is accompanied by unwanted side effects and variable bioavailability that compromise a positive therapeutic outcome. As the main site of infection is the lungs, it is desirable to develop a therapeutic formulation to be administered via the pulmonary route.: This work presents a literature review on studies investigating inhalable dry powder formulations including rifampicin in the context of an experimental tuberculosis therapy, with a special focus on aerosol performance.: It was found that formulation approaches involving different strategies and functional excipients are under investigation but as of now, no formulation has managed to leap into commercial clinical testing. Reasons for this might not primarily be associated with a lack of suitable candidates, but amongst others a lack of suitable models to assess the efficacy, therapeutic benefit, and cost-effectiveness of the candidate formulations.

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Source
http://dx.doi.org/10.1080/17425247.2020.1720644DOI Listing

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