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Immunologic impact of chemoradiation in cervical cancer and how immune cell infiltration could lead toward personalized treatment. | LitMetric

AI Article Synopsis

  • - The study analyzed tumor-infiltrating immune cells (ICs) as potential biomarkers in 38 cervical cancer patients treated with (chemo)radiotherapy and surgery, looking at changes in immune cell markers before and after treatment.
  • - Key immune cell markers evaluated included T cells (CD3, CD4, CD8, FoxP3), macrophages (CD68, CD163), and B cells (CD20), with findings indicating that certain combinations of these markers correlated with better pathological complete response (pCR) and cause-specific survival (CSS).
  • - The results suggested that the immune cell landscape within tumors could help predict patient outcomes and responses to treatment, with certain patterns in immune cell scores linked to more favorable

Article Abstract

We investigated the potential of tumor-infiltrating immune cells (ICs) as predictive or prognostic biomarkers for cervical cancer patients. In total, 38 patients treated with (chemo)radiotherapy and subsequent surgery were included in the current study. This unique treatment schedule makes it possible to analyze IC markers in pretreatment and posttreatment tissue specimens and their changes during treatment. IC markers for T cells (CD3, CD4, CD8 and FoxP3), macrophages (CD68 and CD163) and B cells (CD20), as well as IL33 and PD-L1, were retrospectively analyzed via immunohistochemistry. Patients were grouped in the low score or high score group based on the amount of positive cells on immunohistochemistry. Correlations to pathological complete response (pCR), cause-specific survival (CSS) and metastasis development during follow-up were evaluated. In analysis of pretreatment biopsies, significantly more pCR was seen for patients with CD8 = CD3, CD8 ≥ CD4, positive IL33 tumor cell (TC) scores, IL33 IC < TC and PD-L1 TC ≥5%. Besides patients with high CD8 scores, also patients with CD8 ≥ CD4, CD163 ≥ CD68 or PD-L1 IC ≥5% had better CSS. In the analysis of posttreatment specimens, less pCR was observed for patients with high CD8 or CD163 scores. Patients with decreasing CD8 or CD163 scores between pretreatment and posttreatment samples showed more pCR, whereas those with increasing CD8 or decreasing IL33 IC scores showed a worse CSS. Meanwhile, patients with an increasing CD3 score or stable/increasing PD-L1 IC score showed more metastasis during follow-up. In this way, the intratumoral IC landscape is a promising tool for prediction of outcome and response to (chemo)radiotherapy.

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Source
http://dx.doi.org/10.1002/ijc.32893DOI Listing

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