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Increased parietal operculum functional connectivity following vestibular rehabilitation in benign paroxysmal positional vertigo patients with residual dizziness: a randomized controlled resting-state fMRI study.
Neuroradiology
January 2025
Department of Neurology, Second Affiliated Hospital of Xuzhou Medical University, No. 32, Meijian Road, Quanshan District, Xuzhou, 221006, Jiangsu, China.
Introduction: Residual dizziness (RD) is common in patients with benign paroxysmal positional vertigo (BPPV) after successful canalith repositioning procedures. This study aimed to investigate the therapeutic effects of vestibular rehabilitation (VR) on BPPV patients experiencing RD, and to explore the impact of VR on functional connectivity (FC), specifically focusing on the bilateral parietal operculum (OP) cortex.
Methods: Seventy patients with RD were randomly assigned to either a four-week VR group or a control group that received no treatment.
DFedGFM: Pursuing global consistency for Decentralized Federated Learning via global flatness and global momentum.
Neural Netw
December 2024
The School of Cyber Science and Technology, Shenzhen Campus of Sun Yat-sen University, Shenzhen, 518107, China. Electronic address:
To tackle high communication costs and privacy issues in Centralized Federated Learning (CFL), Decentralized Federated Learning (DFL) is an alternative. However, a significant discrepancy exists between local updates and the expected global update, known as client drift, which arises from inconsistency and heterogeneous data. Previous research in the DFL field has focused on local information during client updates, without considering global information, which fails to alleviate the client drift issue.
View Article and Find Full Text PDF[Research progresses in gene therapy for hepatolenticular degeneration].
Zhonghua Gan Zang Bing Za Zhi
January 2025
Prenatal Diagnosis Center, Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University, Hefei230022, China NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical University), Hefei230032, China Engineering Research Center of Biopreservation and Artificial Organs, Ministry of Education, Hefei230032, China Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People's Republic of China, Hefei230032, China Anhui Province Key Laboratory of Reproductive Disorders and Obstetrics and Gynecology Diseases, Hefei230032, China Biopreservation and Artificial Organs, Anhui Provincial Engineering Research Center, Anhui Medical University, Hefei230032, China Anhui Provincial Institute of Translational Medicine, Hefei230032, China.
Hepatolenticular degeneration, also known as Wilson's disease, is a type of autosomal recessive genetic disorder of copper metabolism. The causative gene, ATP7B, is located on the long arm of chromosome 13 and encodes a P-type ATPase that is involved in copper transport. Pathogenic mutations in the ATP7B gene sequence lead to the diminished or lost function of the ATP7B protein, resulting in pathological copper deposition in organs such as the liver, brain, kidneys, and cornea.
View Article and Find Full Text PDFThe interplay of gut microbiota and heavy metals in multiple sclerosis patients.
Microb Pathog
December 2024
Department of Biology, Faculty of Science, Arak University, Arak, 38156-8-8349, Iran.
Article Synopsis
- Multiple Sclerosis (MS) patients show significantly higher concentrations of heavy metals like arsenic, nickel, manganese, and zinc in their stool compared to healthy individuals, while levels of iron, lead, titanium, and tin are notably lower.
- The study also reveals alterations in the gut microbiome of MS patients, with increased abundance of certain bacterial families indicative of potential changes associated with the disease.
- The research highlights a novel approach by combining heavy metal measurement and gut microbiome analysis, suggesting new insights into the disease's pathogenesis and possible therapeutic strategies.
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