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Estrogens and breast cancer.
Ann Oncol
November 2024
Department of Medicine, Center for BRCA Research, UCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, USA.
Estrogens have been associated with an increase in breast cancer risk. Yet emerging clinical and experimental evidence points to progestogens [endogenous progesterone or synthetic progesterone (progestin)] as the primary hormonal driver underlying seemingly estrogen-associated breast cancer risk. Estrogens may contribute to breast cancer risk indirectly by induction of the progesterone receptor and thus amplifying progesterone signaling.
View Article and Find Full Text PDFAlzheimer's Disease and (Phyto) Estrogen Treatment: Modification of Effects by Age, Type of Treatment, and Duration of Use.
J Alzheimers Dis
October 2024
School of Sports Exercise and Health Sciences, Loughborough University, Loughborough, UK.
Background: There is a continued debate on whether menopausal hormone therapy (MHT) protects women against Alzheimer's disease (AD). It is also unclear whether phytoestrogen could be an alternative treatment for AD.
Objective: To investigate whether mixed study findings may be due to differences in age at initiation of MHT and duration of prescription of different types of MHT using meta-analyses.
Real-World Effectiveness of Menopausal Hormone Therapy in Preventing Relapse in Women With Schizophrenia or Schizoaffective Disorder.
Am J Psychiatry
October 2024
Department of Psychiatry, University Medical Center Groningen, Groningen, the Netherlands (Brand, Sommer, Gangadin); Department of Forensic Psychiatry, University of Eastern Finland, Niuvanniemi Hospital, Kuopio, Finland (Tanskanen, Tiihonen, Taipale); Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden (Tanskanen, Tiihonen, Taipale); Center for Psychiatry Research, Stockholm City Council, Stockholm, Sweden (Tanskanen, Tiihonen, Taipale).
Article Synopsis
- The study examines the impact of menopausal hormone therapy (MHT) on preventing psychosis relapse in women aged 40-62 with schizophrenia or schizoaffective disorder (SSD).
- Results indicated that MHT use led to a 16% reduction in relapse risk, particularly for women aged 40-55.
- The findings highlight the potential of MHT as a beneficial treatment option for preventing psychosis relapse in menopausal women, suggesting that current antipsychotic treatments may not be enough for this group.
Systematic review and meta-analysis of the effects of progestins on depression in post-menopausal women: An evaluation of randomized clinical studies that used validated questionnaires.
Maturitas
November 2024
Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Infant Health, University of Genoa, 16132 Genova, GE, Italy; Academic Unit of Obstetrics and Gynecology, IRCCS Ospedale San Martino, 16132 Genoa, GE, Italy.
Article Synopsis
- This systematic review examines the effects of progestins as part of hormone therapy on depressive symptoms in postmenopausal women, focusing on various validated depression assessment scales.* -
- It analyzed 16 randomized clinical trials and found that adding progestins to estrogen hormone therapy did not worsen depressive symptoms and could improve them over time, although similar improvements were noted with estrogen alone.* -
- The review concluded that while progestins can be effective, the combination of estrogen with fluoxetine may lead to even greater reductions in depressive symptoms compared to hormones alone.*
Menopausal Hormone Therapy, an Ever-Present Topic: A Pilot Survey about Women's Experience and Medical Doctors' Approach.
Medicina (Kaunas)
May 2024
Department of Translational Medicine, University of Piemonte Orientale, Gynecology and Obstetrics, "Maggiore della Carità" Hospital, 28100 Novara, Italy.
: Menopause can be associated with many clinical manifestations: vasomotor symptoms, urogenital problems, and additional psychological disturbances, such as anxiety, mood changes, and sleep alterations. The prolonged lack of hormones also increases the risk of long-term consequences. Hormone Replacement Treatment (HRT) in menopause consists of the administration of estrogen, alone or associated to progesterone, to relieve these uncomfortable disturbances and to prevent the onset of other pathologic conditions.
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