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| http://dx.doi.org/10.1016/j.jdcr.2019.12.008 | DOI Listing |
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Comparison between dutasteride and finasteride in hair regrowth and reversal of miniaturization in male and female androgenetic alopecia: a systematic review.
Dermatol Reports
November 2024
Department of Dermatology, King Saud University Medical City, Riyadh.
Nowadays androgenetic alopecia (AGA) has become a common concern of affected subjects of both sexes. Finasteride is approved by the Food and Drug Administration for the treatment of male AGA. There is no clear evidence to support the use of dutasteride in male AGA.
View Article and Find Full Text PDFBackground And Aims: Metformin is a widely used oral agent for controlling diabetes mellitus, but it also has other therapeutic benefits for various conditions. In addition, conventional oral metformin, and topical metformin have been used in, in-vitro studies in the treatment of acne, psoriasis, wound healing, and and so forth. While topical metformin has shown promising results in animal studies, there is limited data on its effectiveness in humans.
View Article and Find Full Text PDFBaricitinib-loaded EVs promote alopecia areata mouse hair regrowth by reducing JAK-STAT-mediated inflammation and promoting hair follicle regeneration.
Drug Discov Ther
December 2024
Department of Dermatology, Fourth Medical Center of Chinese PLA General Hospital, Beijing, China.
Alopecia areata (AA) is a common and recurrent type of hair loss. Despite oral administration of baricitinib exerts a good effect on refractory AA, the long-term administration of baricitinib carries significant side effects, poor compliance, and the efficacy is difficult to maintain after drug withdrawal. Therefore, the exploration of a safe and effective local administration of baricitinib to treat AA is of great clinical importance.
View Article and Find Full Text PDFAssessment and Validity of Trichoscopy for Eyebrow Involvement in Lichen Planopilaris and Frontal Fibrosing Alopecia: A Case-Control Study.
Dermatol Pract Concept
October 2024
Dermatology Department, University Hospital Cheikh Khalifa, and the University Hospital Mohammed VI Faculty of Medicine, Mohammed VI University of Health and Sciences (UM6SS), Casablanca, Morocco.
Introduction: Few publications are available on eyebrow trichoscopy in patients with alopecia areata and frontal fibrosing alopecia (FFA).
Objective: To investigate the validity of using trichoscopy to examine eyebrow involvement in patients with lichen planopilaris (LPP) and FFA.
Methods: In this case-control study, 109 patients with eyebrow involvement in LPP and FFA (cases) and with acquired hair disorders of the eyebrows (controls) were included.
Dupilumab and Alopecia Areata: A Possible Combined or Disturbance Therapy? A Review of The Literature.
Dermatol Pract Concept
October 2024
Dermatology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico S. Orsola-Malpighi, Bologna, Italy.
Introduction: Dupilumab, a monoclonal antibody targeting IL-4 receptor subunit alpha, treats atopic dermatitis (AD) and may impact alopecia areata (AA). AA involves Th1-driven immune activity, and recent studies suggest a role for Th2 pathways. Dupilumab's effects on AA are mixed, with reports of both improvement and worsening.
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