AI Article Synopsis
- The study examines the relationship between sputum levels of periostin and airway inflammation in patients with Chronic Rhinosinusitis (CRS) and asthma.
- Research showed that CRS patients with asthma had higher sputum periostin levels and more severe olfactory dysfunction compared to those without asthma and healthy controls.
- The findings suggest that increased levels of periostin and inflammatory cells like eosinophils and neutrophils indicate interactions between the upper and lower airways of CRS patients, regardless of asthma presence.
Article Abstract
Background: Chronic rhinosinusitis (CRS) and asthma are collectively called unified airway diseases. Periostin has been implicated in the pathophysiologic link of these conditions but only by serum measurements. We sought to investigate sputum levels of periostin and their association with upper airway inflammation and olfactory function in CRS patients.
Methods: We prospectively recruited 56 CRS patients who underwent endoscopic sinus surgery (20 with and 36 without comorbid asthma), and 28 healthy controls between October 2015 and December 2017. Lower and upper airway indices such as sputum periostin levels and eosinophil and neutrophil counts, exhaled fractional nitric oxide (FeNO) levels, and olfactory function were evaluated in the three groups. Radiological severity of CT images and tissue eosinophilia of surgical specimens were also assessed in the CRS patients.
Results: Sputum periostin levels were highest, and olfactory function was most impaired, in the CRS patients with comorbid asthma, followed by those without asthma and controls in this order. CRS with asthma group showed higher sputum eosinophils and FeNO levels than the other two groups, while CRS patients without asthma showed significantly higher neutrophils in sputum than the other two groups. When confined to CRS patients, olfactory dysfunction was correlated with sputum eosinophil counts. Eosinophil counts of nasal polyps showed a significant positive correlation with sputum periostin and FeNO levels. Radiological severity of CRS was correlated with sputum eosinophil counts and FeNO levels.
Conclusions: Periostin levels and inflammatory cells such as eosinophils and neutrophils in the lower airways are increased in patients with CRS, suggesting the presence of mutual interactions between upper and lower airways even if asthma does not coexist. Olfactory dysfunction and eosinophilic nasal polyps may be potential indicators of Th2-driven inflammation in the lower airways.
Trial Registration: This study was registered on the UMIN Clinical Trials Registry (Registry ID UMIN000018672).
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6992843 | PMC |
| http://dx.doi.org/10.1016/j.waojou.2019.100094 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Prognostic Factors in Severe Eosinophilic Asthma in a Pediatric Population: A Prospective Cohort Study in Spain.
J Clin Med
November 2024
Pneumology Department, Severe Asthma Unit, Hospital Universitari Germans Trias i Pujol, Faculty of Medicine, Universitat Autònoma de Barcelona (UAB), 08916 Badalona, Spain.
: The objective of this study was to provide real-world data on prognostic factors in children with severe eosinophilic asthma and to assess biomarkers of outcome. : Fifty-nine children (aged 6-17 years) were included in a prospective cohort attended in a Severe Asthma Unit of a tertiary care teaching hospital in Badalona (Barcelona, Spain) and visited at baseline and at 1-year follow-up. Study variables included asthma control using the Asthma Control Test (ACT), forced expiratory volume in one second (FEV), exacerbation episodes, fractional exhaled nitric oxide (FeNO), and inflammatory biomarkers (blood tests, sputum cells, immunoallergic tests, and levels of cytokines and effector cells in blood and sputum).
View Article and Find Full Text PDFBlood eosinophil count correlates with alveolar damage in emphysema-predominant COPD.
BMC Pulm Med
October 2024
Department of Respiratory Medicine, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan.
Article Synopsis
- Blood eosinophil count is a significant biomarker for managing chronic obstructive pulmonary disease (COPD), but its precise role in the disease still needs further exploration.
- A study with 93 COPD patients showed that 19.3% had eosinophilic COPD, and while eosinophil counts correlated with some blood parameters, they also indicated lung structural changes related to the disease.
- The findings suggest that elevated eosinophils may contribute to alveolar damage and thickening of airway walls in COPD patients lacking asthma, highlighting the need for further research on this inflammation type in COPD.
Severe Eosinophilic Asthma or Eosinophilic Granulomatosis With Polyangiitis: Potential Biomarkers for Novel Diagnostic Strategies.
J Allergy Clin Immunol Pract
November 2024
Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Background: Severe eosinophilic asthma (SEA) may be the prodromal phase of eosinophilic granulomatosis with polyangiitis (EGPA). Nevertheless, few studies have tried to recognize EGPA in the early stages of the disease.
Objective: To identify a panel of clinical and biological markers to detect which severe asthmatic patient might be considered in a prodromal phase of EGPA and crafting a strategy for diagnostic decision-making.
Biomarkers in asthma, potential for therapeutic intervention.
J Asthma
November 2024
Department of Molecular and Cellular Physiology, Albany Medical College, Albany, NY, USA.
Asthma is a heterogeneous disease characterized by multiple phenotypes with varying risk factors and therapeutic responses. This Commentary describes research on biomarkers for T2-"high" and T2-"low" inflammation, a hallmark of the disease. Patients with asthma who exhibit an increase in airway T2 inflammation are classified as having T2-high asthma.
View Article and Find Full Text PDFResponse of sputum periostin to anti-T2 biologics treatment in severe asthma.
Allergy
October 2024
Division of Medical Biochemistry, Department of Biomolecular Sciences, Saga Medical School, Saga, Japan.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!