RNA secondary structure is critical to RNA regulation and function. We report a new N-kethoxal reagent that allows fast and reversible labeling of single-stranded guanine bases in live cells. This N-kethoxal-based chemistry allows efficient RNA labeling under mild conditions and transcriptome-wide RNA secondary structure mapping.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7182492 | PMC |
| http://dx.doi.org/10.1038/s41589-019-0459-3 | DOI Listing |
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