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A pneumonia outbreak associated with a new coronavirus of probable bat origin. | LitMetric

AI Article Synopsis

  • * A new coronavirus, named 2019-nCoV, was identified during an outbreak in Wuhan, China, which began on December 12, 2019, leading to nearly 2,800 infections and 80 deaths by January 26, 2020.
  • * The genetic analysis shows that 2019-nCoV is 79.6% similar to SARS-CoV and 96% similar to a bat coronavirus, and it enters human cells using the same receptor (ACE2) as SARS-CoV.

Article Abstract

Since the outbreak of severe acute respiratory syndrome (SARS) 18 years ago, a large number of SARS-related coronaviruses (SARSr-CoVs) have been discovered in their natural reservoir host, bats. Previous studies have shown that some bat SARSr-CoVs have the potential to infect humans. Here we report the identification and characterization of a new coronavirus (2019-nCoV), which caused an epidemic of acute respiratory syndrome in humans in Wuhan, China. The epidemic, which started on 12 December 2019, had caused 2,794 laboratory-confirmed infections including 80 deaths by 26 January 2020. Full-length genome sequences were obtained from five patients at an early stage of the outbreak. The sequences are almost identical and share 79.6% sequence identity to SARS-CoV. Furthermore, we show that 2019-nCoV is 96% identical at the whole-genome level to a bat coronavirus. Pairwise protein sequence analysis of seven conserved non-structural proteins domains show that this virus belongs to the species of SARSr-CoV. In addition, 2019-nCoV virus isolated from the bronchoalveolar lavage fluid of a critically ill patient could be neutralized by sera from several patients. Notably, we confirmed that 2019-nCoV uses the same cell entry receptor-angiotensin converting enzyme II (ACE2)-as SARS-CoV.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095418PMC
http://dx.doi.org/10.1038/s41586-020-2012-7DOI Listing

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