AI Article Synopsis
- Prostate cancer is prevalent among men, with metastatic cases leading to higher mortality rates.
- High levels of Kisspeptin (KISS1) and its receptor (KISS1R) are found in localized prostate tumors compared to advanced stages.
- The reduced expression of the KISS1-KISS1R system in advanced prostate cancer suggests it could be a potential marker for diagnosis and a target for treatment.
Article Abstract
Background/aim: Prostate cancer (PCa) is the second most commonly diagnosed cancer in men. In contrast to localized disease, metastatic PCa leads to increased mortality. Kisspeptin (KISS1) functions as a metastasis suppressor in various cancers. The aim of this study was to detect the expression of KISS1 and its receptor GPR54 (KISS1R) in prostate cancer.
Materials And Methods: The expression of KISS1 and KISS1R was examined in prostate cancer tissue specimens after radical prostatectomy.
Results: A higher expression of KISS1 and KISS1R was shown in patients with localized tumors (Stage ≤IIb) compared to patients with advanced (Stage ≥III) tumor. High Gleason score PCa and higher prognostic groups patients showed a lower expression rate of both KISS1 and KISS1R.
Conclusion: A down-regulation of KISS1-KISS1R system was detected in advanced prostate cancer. KISS1as tumor suppressor might be useful in the future for the diagnosis, risk assessment of prostate cancer progression, as well as a therapeutic target for aggressive tumors.
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| http://dx.doi.org/10.21873/anticanres.14001 | DOI Listing |
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