AI Article Synopsis
- The traditional view of cancer as solely a cell-autonomous disease is shifting, highlighting the crucial role of the tumor microenvironment (TM) in cancer growth and spread.
- Endothelial cells (ECs), once mainly seen as involved in forming blood vessels, are now recognized for their non-angiogenic functions that influence both normal and pathological tissue development.
- Recent studies have shown that tumor-associated endothelial cells display unique gene expression and interact closely with tumors, revealing potential new targets for therapies aimed at disrupting these interactions.
Article Abstract
The concept of cancer as a cell-autonomous disease has been challenged by the wealth of knowledge gathered in the past decades on the importance of tumor microenvironment (TM) in cancer progression and metastasis. The significance of endothelial cells (ECs) in this scenario was initially attributed to their role in vasculogenesis and angiogenesis that is critical for tumor initiation and growth. Nevertheless, the identification of endothelial-derived angiocrine factors illustrated an alternative non-angiogenic function of ECs contributing to both physiological and pathological tissue development. Gene expression profiling studies have demonstrated distinctive expression patterns in tumor-associated endothelial cells that imply a bilateral crosstalk between tumor and its endothelium. Recently, some of the molecular determinants of this reciprocal interaction have been identified which are considered as potential targets for developing novel anti-angiocrine therapeutic strategies.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6998193 | PMC |
| http://dx.doi.org/10.1186/s12967-020-02244-9 | DOI Listing |
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