Only a handful of primate species exhibit the social relationship of pair-bonding. Efficient communication is critical for behavioral coordination within pair-bonds to maintain proximity and respond appropriately to extra-pair individuals, and possibly coordinate infant care. The use of complex signaling across modalities may help individuals improve communicative outcomes. We review many ways that pair-bonded species use signals to communicate and maintain bonds, though little previous research has taken a truly multimodal approach within a single species. We make a call for further investigation into pair-bonded communication using a multimodal approach to better understand how these species use all their senses to build, maintain, and advertise their bonds.
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Sci China Life Sci
January 2025
Institute of Cardiovascular Sciences, School of Basic Medical Sciences, Peking University Health Science Center; Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital; State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, Beijing, 100191, China.
Diffuse-type tenosynovial giant cell tumor (dTGCT) is a destructive but rare benign proliferative synovial neoplasm. Although surgery is currently the main treatment modality for dTGCT, the recurrence risk is up to 50%. Therefore, there is a great need for effective drugs against dTGCT with minor side effects.
View Article and Find Full Text PDFTurk J Pediatr
December 2024
Department of Pediatric Hematology Oncology, Ankara Bilkent City Hospital, Ankara Yıldırım Beyazıt University, Ankara, Türkiye.
Background: The management of pediatric acute myeloid leukemia (AML) is based on the prognostic risk classification of initial leukemia. Targeted next-generation sequencing (NGS) is a reliable method used to identify recurrently mutated genes of pediatric AML and associated prognosis.
Methods: In this study, we retrospectively evaluated the prognostic, and therapeutic utility of a targeted NGS panel covering twenty-five genes, in 21 children with de novo and 8 with relapsed or secondary AML.
Math Biosci Eng
December 2024
School of Information Engineering, Nantong Institute of Technology, Nantong 226002, Jiangsu, China.
As an essential component of mechanical systems, bearing fault diagnosis is crucial to ensure the safe operation of the equipment. However, vibration data from bearings often exhibit non-stationary and nonlinear features, which complicates fault diagnosis. To address this challenge, this paper introduces a novel multi-scale time-frequency and statistical features fusion model (MTSF-FM).
View Article and Find Full Text PDFCancer Lett
January 2025
Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA; Peggy and Charles Stephenson Cancer Center, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA. Electronic address:
The tumor microenvironment (TME) plays a pivotal role in cancer progression by fostering intricate multicellular crosstalk among cancer cells, stromal cells, and immune cells. This review explores the emerging paradigm of utilizing nanoparticles to disrupt this crosstalk within the TME as a therapeutic strategy. Nanoparticles are engineered with precise physicochemical properties to target specific cell types and deliver therapeutic payloads, thereby inhibiting critical signaling pathways involved in tumor growth, invasion, and metastasis.
View Article and Find Full Text PDFF-Florbetaben (FBB) uptake in the supratentorial cortex is indicative of amyloid positivity. Due to PET's low spatial resolution, image noise, and spill-over of signal from adjacent white-matter into gray-matter, there are inconsistencies in ratings among trained readers. A set of 264 F-Florbetaben (amyloid) PET/MRI exams were reconstructed using conventional ordered subset expectation maximization (OSEM) method and MR-guided block sequential regularized expectation maximization (MRgBSREM) method.
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