AI Article Synopsis
- - The rs10757274 SNP, found in the CDKN2BAS1 gene at locus 9p21, has been studied for its possible link to coronary artery disease (CAD), prompting a meta-analysis to clarify its association due to mixed prior results.
- - The meta-analysis, which included data from 11 studies with over 52,000 participants, showed a significant relationship between the rs10757274 polymorphism and CAD risk across multiple statistical models.
- - The results suggest that rs10757274 could be a genetic biomarker for CAD, particularly in West Asian populations, despite significant variability between individual studies.
Article Abstract
Background: It has been reported the rs10757274 SNP (present on locus 9p21 in the gene for CDKN2BAS1) might be associated with susceptibility to coronary artery disease (CAD). Owing to mixed and inconclusive results, we conducted a meta-analysis to investigate the association between rs10757274 polymorphism and the risk of CAD.
Objectives: The present study aimed to investigate the relationship between rs10757274 polymorphism and the risk of CAD.
Methods: All studies of the rs10757274 SNP with CAD that were published between 2007 and 2018 were retrieved from the PubMed database. Meta-analysis was performed with Stata 14.0 software. The effect size of the rs10757274 SNP with CAD risk was assessed based on the odds ratios (ORs) with calculation of 95% confidence interval (CI).
Results: Eleven studies including 52,209 subjects (cases: 7990, controls: 44,219) were included in the final data combination. Pooled overall analyses showed that rs10757274 (allele model: P < .001; dominant model: P < .001; recessive model: P < .001; Heterozygote codominant: P = .002; Homozygote codominant: P < .001) polymorphisms were significantly associated with the likelihood of CAD. Significant heterogeneity between individual studies appears in all 5 models. Further subgroup analyses revealed that rs10757274 polymorphisms were all significantly correlated with the likelihood of CAD and no heterogeneity were observed in West Asians.
Conclusions: Our findings indicated that rs10757274 polymorphisms may serve as genetic biomarkers of CAD, especially in West Asians.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220330 | PMC |
| http://dx.doi.org/10.1097/MD.0000000000018841 | DOI Listing |
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