Synthesis, anti-oomycete activity, and SAR studies of paeonol derivatives.

Three series of sulfonate derivatives of paeonol were synthesized and screened for their anti-oomycete activity against , respectively. Among all the compounds, displayed the best promising and pronounced anti-oomycete activity against than zoxamide, with the EC values of 24.51 and 26.87 mg/L, respectively. The results show that acetyl and 4-OCH are two necessary groups. The existence of these two sites is closely related to the anti-oomycete activity. Relatively speaking, hydroxyl group is well tolerated, and the results showed that after modification of hydroxyl group with sulfonyl, the anti-oomycete activity was significantly increased. [Formula: see text].