AI Article Synopsis
- Recent findings show significant genetic diversity in Torque teno sus viruses (TTSuV1 and TTSuVk2), highlighting a need for better detection methods.
- A new single PCR-based detection technique was developed to identify TTSuV1 and TTSuVk2a genomes using tailored primer pairs.
- In a study of Japanese pig populations, the prevalence was found to be extremely high, with 98.2% of farms testing positive for TTSuV1 and 81.7% for TTSuVk2a.
Article Abstract
Because broad genetic diversity has recently been detected in Torque teno sus viruses (TTSuV1 and TTSuVk2), the viral genome detection method needs to be improved to understand the prevalence of these viruses. Here, we established single PCR-based detection methods for the TTSuV1 and TTSuVk2a genomes with newly designed primer pairs and applied them to investigate the prevalence of TTSuV1 and TTSuVk2a in Japanese pig populations. The results revealed that 98.2% and 81.7% of the pig farms tested positive for the TTSuV1 and TTSuVk2a genomes, respectively, indicating that both TTSuV1 and TTSuVk2a are widespread in Japan.
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Characterization of two newly emerged torque teno sus virus isolates from a large-scale pig farm in China, in 2018.
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May 2021
State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, PR China. Electronic address:
Torque teno sus virus (TTSuV) infection is common in China's pig herd. Although of uncertain pathogenicity, TTSuVs have been reported as a worsening factor of other porcine diseases, including porcine circovirus associated disease (PCVAD), porcine respiratory diseases complex (PRDC) or porcine dermatitis and nephropathy syndrome (PDNS). To better understand the genetic diversity in TTSuVs, the complete genomes of two newly emerged isolates, referred to as HeN1-A9 and HeN1-A11, collected from pig samples at a large-scale pig farm in China, were analyzed.
View Article and Find Full Text PDFEpidemiology and evolutionary analysis of Torque teno sus virus.
Vet Microbiol
May 2020
MOE Joint International Research Laboratory of Animal Health and Food Safety, Jiangsu Engineering Laboratory of Animal Immunology, Institute of Immunology and College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China. Electronic address:
Single stranded (ss) DNA viruses are increasingly being discovered due to the ongoing development of modern technologies in exploring the virosphere. Characterized by high rates of recombination and nucleotide substitutions, it could be comparable to RNA virus ones. Torque teno sus virus (TTSuV) is a standard ssDNA virus with a high population diversity, whose evolution is still obscure, further, it is frequently found in co-infections with other viruses threatening the porcine industry and therefore share the same host and epidemiological context.
View Article and Find Full Text PDFNationwide prevalence of Torque teno sus virus 1 and k2a in pig populations in Japan.
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Article Synopsis
- Recent findings show significant genetic diversity in Torque teno sus viruses (TTSuV1 and TTSuVk2), highlighting a need for better detection methods.
- A new single PCR-based detection technique was developed to identify TTSuV1 and TTSuVk2a genomes using tailored primer pairs.
- In a study of Japanese pig populations, the prevalence was found to be extremely high, with 98.2% of farms testing positive for TTSuV1 and 81.7% for TTSuVk2a.
Genetic Analysis and Evolutionary Changes of the Torque teno sus Virus.
Int J Mol Sci
June 2019
Key Laboratory of Animal Virology of Ministry of Agriculture, Zhejiang University, Hangzhou 310027, China.
The torque teno sus virus (TTSuV) is an emerging virus threating the species of unclear pathogenicity, although it was previously reported as a worsening factor of other porcine diseases, in particular, porcine circovirus associated disease (PCVAD). Here, a comprehensive codon usage analysis of the open reading frame 1 (ORF1), which encodes the viral capsid protein, was undertaken for the first time to reveal its evolutionary history. We revealed independent phylogenetic processes for the two genera during TTSuV evolution, which was confirmed by principal component analysis (PCA).
View Article and Find Full Text PDFHigh frequency and extensive genetic heterogeneity of TTSuV1 and TTSuVk2a in PCV2- infected and non-infected domestic pigs and wild boars from Uruguay.
Vet Microbiol
October 2018
Sección Virología, Facultad de Ciencias, Universidad de la República, Iguá 4225, Montevideo, 11400, Uruguay. Electronic address:
Torque teno sus virus (TTSuV) infection is common worldwide in both healthy and diseased swine and a relationship between this virus and a particular disease in pigs has not been established. This work aimed to investigate the presence of TTSuV1 and TTSuVk2a in Porcine Circovirus type 2 (PCV2)-infected and non-infected domestic pigs and free-living wild boars from Uruguay. Our data evidenced a high frequency of detection and a wide circulation of TTSuV among pig herds and wild boar populations.
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