Replacement blood donations are a major source of blood in KSA. This presentation highlights "the peace time and war experiences," where the voluntary donor potential was tested. THE "PEACETIME EXPERIENCE"-KING SAUD UNIVERSITY STUDENT DONOR DRIVE: This donor drive commenced in 1983 with 13 donors in its first and the annual collection reached 4500 blood units in the academic session 1995-1996, when the student enrollment was around 30,000. In 2018 the enrollment jumped to 120,000 students. If we add the staff and auxiliary personnel, the population of potential voluntary blood donors will be enough to cover the current and future blood needs of King Khalid University Hospital. Unfortunately, this drive did not survive due to administrative and organizational difficulties. THE "FIRST" GULF WAR EXPERIENCE: At the end of 1990, when the Allied Forces started to end the Iraqi occupation of Kuwait, the Saudi Ministry of Health waged a publicity campaign asking healthy individuals to donate their blood. The response was phenomenal, and the blood inventory in blood banks swelled about five- to sevenfold. First-time donors broke the "fear barrier," went through the donation experience, and it is hoped they will return to donate voluntarily. CONCLUSIONS: The major lesson learned from the King Saud University student donor drive and Gulf War experience is the enormous voluntary donor potential in Saudi Arabia. There is a need for forward planning to shift the current partial involuntary donor system to a voluntary system based on nonremunerated donors.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1111/trf.15683 | DOI Listing |
Brain
January 2025
State Key Laboratory of Cardiology and Medical Innovation Center, Shanghai East Hospital, Clinical Center for Brain and Spinal Cord Research, School of Medicine, Tongji University, 200331, Shanghai, China.
Amyotrophic lateral sclerosis (ALS) is a severe motor neuron disease, with most sporadic cases lacking clear genetic causes. Abnormal pre-mRNA splicing is a fundamental mechanism in neurodegenerative diseases. For example, TAR DNA-binding protein 43 (TDP-43) loss-of-function (LOF) causes widespread RNA mis-splicing events in ALS.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
January 2025
National University of Singapore - Kent Ridge Campus: National University of Singapore, Department of Chemistry, Faculty of Science, 3 Science Drive 3, 117543, Singapore, SINGAPORE.
Figure-eight macrocycles represent a fascinating class of π-conjugated units characterized by unique aesthetics and non-contact molecular crossing at the center. Despite progress in synthesis over the past century, research into inorganic, organic, and polymeric figure-eight materials remains in its infancy. Here we report the first examples of figure-eight covalent organic frameworks by condensing figure-eight knots to create extended porous figure-eight π architectures.
View Article and Find Full Text PDFBMC Mol Cell Biol
January 2025
Department of Biochemistry, University at Buffalo, 3435 Main Street, Buffalo, NY, 14214, USA.
Background: Bioengineering of human teeth for replacement is an appealing regenerative approach in the era of gene therapy. Developmentally regulated transcription factors hold promise in the quest because these transcriptional regulators constitute the gene regulatory networks driving cell fate determination. Atonal homolog 1 (Atoh1) is a transcription factor of the basic helix-loop-helix (bHLH) family essential for neurogenesis in the cerebellum, auditory hair cell differentiation, and intestinal stem cell specification.
View Article and Find Full Text PDFGlob Chang Biol
January 2025
Department of Geosciences and Natural Resource Management, University of Copenhagen, Frederiksberg C, Denmark.
Afforestation is increasingly recognized as a critical strategy to restore ecosystems and enhance biodiversity on post-agricultural landscapes. However, agricultural legacies, such as altered soil structure, nutrient imbalances, and depleted microbial diversity, can slow down forest establishment or cause ecosystems to deviate from expected successional trajectories. In this opinion paper, we explore the potential of soil inoculations as a tool to overcome these challenges by introducing beneficial microbial communities that can accelerate ecosystem recovery and forest development.
View Article and Find Full Text PDFJ Control Release
January 2025
Department of Pharmaceutical Engineering, China Pharmaceutical University, Nanjing 211198, China. Electronic address:
Liver fibrosis is a prevalent liver disease associated with significant morbidity, and the activation of hepatic stellate cells (HSCs) serves as the primary causative factor driving the progression of liver fibrosis. However, capillarization of liver sinusoidal endothelial cells (LSECs) induced by hepatic fibrosis can reduce nitric oxide (NO) production and bioavailability, which consequently loses the ability to retain HSCs dormant, leading to amplified HSCs activation. Herein, an elaborate micelle (VN-M@BN) loaded with benazepril (BN) was constructed by self-assembly of polymeric NO donor, aiming for the controlled release of NO in liver fibrosis lesions thereby impeding the progression of liver fibrosis.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!