AI Article Synopsis

  • The study investigates the relationship between left ventricular filling pressure (LVFP) and right atrial pressure (RAP) in patients with suspected heart failure with preserved ejection fraction (HFpEF).
  • It compares the diagnostic effectiveness of measuring the inferior vena cava (IVC) against 2016 echocardiographic guidelines for estimating LVFP.
  • Findings indicate that IVC measurements have higher predictive value for identifying increased LVFP compared to the 2016 recommendations, making IVC size and collapsibility important for diagnosis in both sinus rhythm and atrial fibrillation.

Article Abstract

Context: The left ventricular filling pressure (LVFP) is correlated to right atrial pressure (RAP) in heart failure. We compared diagnostic value of the inferior vena cava (IVC) measurements to the one of the 2016 echocardiographic recommendations to estimate LVFP in patients with suspected heart failure with preserved ejection fraction (HFpEF).

Methods: Invasive hemodynamics and echocardiography were obtained within 48 hours in 132 consecutive patients with left ventricular ejection fraction ≥50%, and suspected pulmonary hypertension. Increased LVFP was defined by a pulmonary artery wedge pressure (PAWP) >15 mmHg.

Results: Of 83 patients in sinus rhythm, a score of the 2016 recommendations ≥ 2 (E/e' ratio >14 and/or tricuspid regurgitation velocity >2.8 m/s and/or indexed left atrial volume>34 mL /m²) had a positive predictive value (PPV) of 63% for PAWP>15 mmHg, whereas a dilated IVC (>2.1 cm) and/or non-collapsible (≤50%) had a PPV of 82%. The net reclassification improvement was 0.39 (P < .05). In atrial fibrillation (AF), a dilated and/or non-collapsible IVC had an 86% PPV for PAWP>15 mmHg. The correlation between RAP and PAWP was 0.60, with 75.7% concordance (100/132) between dichotomized pressures (both RAP>8 mmHg and PAWP>15 mmHg and vice versa).

Conclusion: The IVC size and collapsibility is valuable to identify patients with HFpEF with high LVFP in both sinus rhythm and AF.

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Source
http://dx.doi.org/10.1016/j.cardfail.2020.01.018DOI Listing

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