AI Article Synopsis
- A novel selective cortisol sensor made from poly(glycidylmethacrylate-co-ethylene glycol dimethacrylate) enables rapid cortisol detection in human sweat using an affordable layer-by-layer assembly technique.
- The sensor incorporates a flexible PDMS base with conductive nanoporous films and demonstrates a quick response time of just 3 minutes.
- It offers high sensitivity with a detection limit of 2.0 ng/mL, a dynamic range of 10-66 ng/mL, and maintains stability and specificity, effectively distinguishing cortisol from various other substances.
Article Abstract
A selective cortisol sensor based on molecularly imprinted poly(glycidylmethacrylate-co ethylene glycol dimethacrylate) (poly(GMA-co-EGDMA)) has been demonstrated for detection of cortisol in human sweat. The non-enzymatic biomimetric flexible sweat sensor was fabricated inexpensively by layer by layer (LbL) assembly. The sensor layers comprised a stretchable polydimethylsiloxane (PDMS) base with carbon nanotubes-cellulose nanocrystals (CNC/CNT) conductive nanoporous nanofilms. The imprinted (MIP) poly(GMA-co-EGDMA) deposited on the CNC/CNT was the cortisol biomimetric receptor. Rapid in analyte response (3 min), the cortisol MIP sensor demonstrated excellent performance. The sensor has a limit of detection (LOD) of 2.0 ng/mL ± 0.4 ng/mL, dynamic range of 10-66 ng/mL, and a sensor reproducibility of 2.6% relative standard deviation (RSD). The MIP sensor also had high cortisol specificity and was inherently blind to selected interfering species including glucose, epinephrine, β-estradiol, and methoxyprogestrone. The MIP was four orders of magnitude more sensitive than its non-imprinted (NIP) counterpart. The MIP sensor remains stable over time, responding proportionately to doses of cortisol in human sweat. Graphical abstract.
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| http://dx.doi.org/10.1007/s00216-020-02430-0 | DOI Listing |
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