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A Novel Biodegradable Tubular Stent Prevents Pancreaticojejunal Anastomotic Stricture. | LitMetric

A Novel Biodegradable Tubular Stent Prevents Pancreaticojejunal Anastomotic Stricture.

Sci Rep

Biomedical Engineering Research Center, Asan Institute for Life Sciences, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Republic of Korea.

Published: January 2020

AI Article Synopsis

  • Stricture of pancreatic-enteric anastomoses can occur after pancreaticoduodenectomy, resulting in issues like malnutrition and diabetes.
  • Researchers tested a biodegradable tubular stent (BTS) in rats and pigs to prevent complications from pancreaticojejunostomy (PJ) anastomotic stricture.
  • The study showed successful stent placement and safe degradation, although the control group had better pancreatic duct outcomes, indicating more research is needed before human application.

Article Abstract

Stricture of pancreatic-enteric anastomoses is a major late complication of a pancreaticoduodenectomy for the treatment of a periampullary tumor and can lead to exocrine and endocrine insufficiency such as malnutrition and diabetes mellitus. We investigated the safety and efficacy of a biodegradable tubular stent (BTS) for preventing a pancreaticojejunostomy (PJ) anastomotic stricture in both a rat and porcine model. The BTS was manufactured using a terpolymer comprising poly p-dioxanone, trimethylene carbonate, and glycolide. A cohort of 42 rats was randomized into 7 groups of 6 animals each after BTS placement into the duodenum for the biodegradation assay. A total of 12 pigs were randomized equally into a control and BTS placement group. The effectiveness of the BTS was assessed by comparing radiologic images with histologic results. Surgical procedures and/or BTS placements were technically successful in all animals. The median mass losses of the removed BTS samples from the rat duodenum were 2.1, 6.8, 11.2, 19.4, 26.1, and 56.8% at 1, 2, 3, 4, 6, and 8 weeks, respectively. The BTS had completely degraded at 12 weeks in the rats. In the porcine PJ model, the mean luminal diameter and area of the pancreatic duct in the control group was significantly larger than in the BTS group (all p < 0.05). BTS placement thus appears to be safe and effective procedure for the prevention of PJ anastomotic stricture. These devices have the potential to be used as a temporary stent placement to treat pancreatic-enteric anastomoses, but further investigations are required for optimization in human.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6992790PMC
http://dx.doi.org/10.1038/s41598-019-57271-4DOI Listing

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