AI Article Synopsis
- The study identified bioactive compounds in the ethyl acetate fraction of plant aerial parts that exhibit local anesthetic properties.
- Twelve compounds were separated from the most potent fraction, showing a mean onset time for anesthesia comparable to a standard anesthetic (tetracaine).
- Molecular docking studies indicated that Rabdosiin and Apigenin-7-O-rutinoside are the key compounds for local anesthesia, likely blocking sodium ion channels to prevent pain sensation.
Article Abstract
The present study aimed to detect the bioactive metabolites from aerial parts which are responsible for the local anaesthetic activity of the ethyl acetate fraction. Following a bioassay-guided fractionation, twelve compounds were dereplicated from the ethyl acetate fraction which was the most potent one with a mean onset of action (1.43 ± 0.07****) min compared to tetracaine as a positive control (1.37 ± 0.07****) min. These compounds, along with seven other compounds (isolated by diverse chromatographic techniques) were subjected to a molecular docking study to declare the top scoring compounds predicted to be responsible for such activity. The results highlighted Rabdosiin and Apigenin-7-O-rutinoside as the main bioactive leaders of the local anaesthesia forming multiple H- bonding with the sodium ion channels leading to their blockade and loss of pain sensation, which strongly supports the use of as a local anaesthetic agent.
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| http://dx.doi.org/10.1080/14786419.2020.1719489 | DOI Listing |
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