AI Article Synopsis
- Hypertrophic scarring (HSc) is a persistent issue that impacts millions in terms of physical, psychological, and economic well-being.
- Advances in surgical and wound care techniques haven't completely resolved the challenges in preventing and treating HSc.
- The article reviews current understanding of factors that contribute to HSc development and the underlying cellular and molecular mechanisms involved.
Article Abstract
Hypertrophic scarring (HSc) is an age-old problem that still affects millions of people physically, psychologically, and economically. Despite advances in surgical techniques and wound care, prevention and treatment of HSc remains a challenge. Elucidation of factors involved in the development of this common fibroproliferative disorder is crucial for further progress in preventive and/or therapeutic measures. Our knowledge about pathophysiology of HSc at the cellular and molecular level has grown considerably in recent decades. In this article, current knowledge of predisposing factors and the cellular and molecular mechanisms of HSc has been reviewed.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6990447 | PMC |
| http://dx.doi.org/10.1093/jbcr/irz158 | DOI Listing |
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