Melipatulinones A-C, Three Lignan-Phloroglucinol Hybrids from .

(±)-Melipatulinones A-C (-), three unique enantiomeric pairs of lignan-phloroglucinol hybrids along with the biogenetically related compound melipatulignan A (), were isolated from the leaves of . Melipatulinones A () and B () share a novel spiro[hydrobenzofuran-2,3'-furan] 5/5/6 tricyclic ring system, while melipatulinone C () features an unprecedented spiro[cyclopenta[]hydrofuran-2,3'-furan] 5/5/5 tricyclic framework. Their structures were determined by spectroscopic methods, electronic circular dichroism (ECD) calculations, and X-ray diffraction. Compounds - exhibited a pancreatic lipase inhibitory effect.