AI Article Synopsis
- - Double-hit lymphoma (DHL) is a rare and aggressive form of non-Hodgkin lymphoma that involves specific gene rearrangements (MYC, BCL2, BCL6) and typically doesn't respond well to standard chemotherapy.
- - Although it's uncommon for lymphomas to arise in the oral cavity or tonsils, a case is reported involving a 44-year-old male with well-controlled HIV who experienced a sore throat and a rapidly growing tonsillar mass.
- - Pathological analysis revealed that the tonsillar mass had genetic rearrangements indicative of DHL, highlighting the importance of considering lymphoma in young patients with similar symptoms for timely treatment and to avoid serious complications.
Article Abstract
Double-hit lymphoma (DHL) is a unique subtype of non-Hodgkin lymphoma characterized by atleast two rearrangements involving MYC, BLC2, and/or BCL6. These lymphomas are uncommon and aggressive, responding poorly to typical chemotherapy regimens. Lymphomas rarely arise from the oral cavity or tonsils, and those presenting as a neck mass are predominantly diffuse large B-cell lymphoma. To date, primary DHL of the tonsils has yet to be described in the literature. Here, we report a case of a 44 year-old male patient with well-controlled human immunodeficiency virus (HIV) who presented with a sore throat. He subsequently developed acute respiratory compromise due to a rapidly enlarging tonsillar mass. Pathologic and genetic analysis confirmed the presence of BCL6 and MYC rearrangements suggestive of DHL of the tonsils. In a young patient with HIV and a neck mass, it is essential that lymphoma remains on the list of differential diagnoses as prompt diagnosis and treatment may prevent complications from its rapid expansion.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7669924 | PMC |
| http://dx.doi.org/10.1007/s12105-020-01135-1 | DOI Listing |
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