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Multifunctional carboxymethyl chitosan/oxidized carboxymethyl cellulose hydrogel loaded with ginsenoside Rg1 and polydopamine nanoparticles for infected diabetic wound healing.
Int J Biol Macromol
December 2024
Luzhou Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Luzhou, China; Institute of Stomatology, Southwest Medical University, Luzhou, China. Electronic address:
Besides bacterial infection, diabetic wounds are often accompanied by local inflammatory response, oxidative stress imbalances, and vascular formation disorders, which are the main reasons for long-term non-healing of diabetic wounds. In order to solve this problem, Ch-OCMC-PDA NPs-Rg1 self-healing hydrogel was constructed by Schiff base reaction. With the addition of PDA NPs and Rg1, Ch-OCMC-PDA NPs-Rg1 hydrogel showed excellent physical properties, like compressive strength of 142 kPa, swelling ratio of 148.
View Article and Find Full Text PDFPredictive Factors for the Healing of Rotator Cuff Repairs.
Cureus
August 2024
Orthopaedics and Traumatology, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), São Paulo, BRA.
Introduction: Rotator cuff tears (RCTs) are a significant cause of shoulder pain. Rotator cuff repair is common, but healing failure is frequent and the reasons for the retear are still unclear.
Objective: This study aimed to determine if specific preoperative factors related to patients and tears affect the structural outcome after rotator cuff repair.
Role of Autologous Platelet-Rich Fibrin in Chronic Non-healing Ulcers With Various Etiologies in a Tertiary Care Rehabilitation Centre: A Case Series.
Cureus
September 2024
Endocrine Surgery, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, IND.
Article Synopsis
- Chronic non-healing ulcers are persistent skin wounds that fail to heal within a normal timeframe due to underlying health issues, significantly impacting rehabilitation and quality of life.
- A case series involving eight wounds from six patients utilized platelet-rich fibrin (PRF) treatment, with weekly applications leading to monitored healing progress using metrics like PUSH scores and wound size.
- Results showed varying healing rates, with complete wound closure in three cases, and an overall improvement in patients' functional independence by nearly 16% during their hospital stay, indicating PRF is a promising treatment option for these challenging wounds.
Immunomodulation Pathogenesis and Treatment of Bone Nonunion.
Orthop Surg
August 2024
Department of Orthopedics and Traumatology (Trauma and Bone-Setting), Laboratory of Integrated Chinese and Western Medicine for Orthopedic and Traumatic Diseases Prevention and Treatment, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, China.
Fractures and bone nonunion commonly require surgical intervention. Serious outcomes of non-healing in the late stages of fracture place a significant financial burden on society and families. Bone nonunion occurs when a fracture stops healing, for many reasons, and leads to a variety of bad outcomes.
View Article and Find Full Text PDFA Qualitative Study of Patients' Lived Experiences of Free Tissue Transfer for Diabetic Foot Disease.
Plast Reconstr Surg Glob Open
May 2024
From the Department of Plastic Surgery, Stoke Mandeville Hospital, Aylesbury, United Kingdom.
Background: Free tissue transfer (FTT) for reconstruction of diabetic foot disease (DFD) is an emerging field to preserve the lower limb within this patient group. The design of future quantitative research and clinical services in this area must consider the needs, expectations and concerns of patients. This qualitative study explores patient experiences of FTT for reconstruction of DFD.
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