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Alzheimer's disease drug development in an evolving therapeutic landscape.
Alzheimers Dement (N Y)
November 2024
Alzheimer's Association Chicago Illinois USA.
Unlabelled: The Alzheimer's disease (AD) research field has entered a new era, where our fundamental understanding of the pathophysiology of AD and advances in biomarkers have not only allowed for earlier, timely, and accurate detection and diagnosis of the disease, but that amyloid removal has been shown to be associated with signals of slowing cognitive and functional decline. Although recent FDA-approved amyloid plaque-lowering monoclonal antibody therapies have shifted the trajectory of AD, additional treatment options will be key to further slowing clinical decline or stopping disease progression. Thus, new and emerging therapies for AD have created an evolving therapeutic landscape.
View Article and Find Full Text PDFExploring happiness factors with explainable ensemble learning in a global pandemic.
PLoS One
January 2025
Department of Sociology, Hajee Mohammad Danesh Science and Technology University, Dinajpur, Bangladesh.
Happiness is a state of contentment, joy, and fulfillment, arising from relationships, accomplishments, and inner peace, leading to well-being and positivity. The greatest happiness principle posits that morality is determined by pleasure, aiming for a society where individuals are content and free from suffering. While happiness factors vary, some are universally recognized.
View Article and Find Full Text PDFPhase evolutions of sodium layered oxide cathodes during thermal fluctuations.
Chem Commun (Camb)
January 2025
College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325035, China.
Layered transition metal oxide (NaTMO) cathodes are considered highly appropriate for the practical applications of sodium-ion batteries (SIBs) owing to their facile synthesis and high theoretical capacity. Generally, the phase evolution behaviors of NaTMO during solid-state reactions at high temperature closely related to their carbon footprint, prime cost, and the eventual electrochemical properties, while the thermal stability in various desodiated states associated with wide temperature fluctuations are extremely prominent to the electrochemical properties and safety of SIB devices. Therefore, in this review, the influences of sintering conditions such as pyrolysis temperature, soaking time, and cooling rates on the phase formation patterns of NaTMO are summarized.
View Article and Find Full Text PDFOptimizing enzyme thermostability by combining multiple mutations using protein language model.
mLife
December 2024
State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic & Developmental Sciences, School of Life Sciences and Biotechnology Shanghai Jiao Tong University Shanghai China.
Article Synopsis
- Optimizing enzyme thermostability is crucial for protein science and industry, but combining multiple mutations can lead to inactivation, making traditional methods slow and inefficient.
- Researchers developed an AI-driven method to enhance enzyme thermostability by efficiently recombining beneficial single-point mutations, using data from various mutant groups.
- After two design rounds, the study achieved 50 combinatorial mutants with 100% success, including one exceptional mutant that significantly increased melting temperature and half-life, while also revealing complex interactions (epistasis) among mutations.
Feeling good, approaching the positive.
Front Psychol
December 2024
Institute of Cognitive Science, University of Osnabrück, Osnabrück, Germany.
Introduction: Approach and avoidance behaviors have been extensively studied in cognitive science as a fundamental aspect of human motivation and decision-making. The Approach-Avoidance Bias (AAB) refers to the tendency to approach positive stimuli faster than negative stimuli and to avoid negative stimuli faster than positive ones. Affect and arousal in involved individuals are assumed to play a crucial role in the AAB but many questions in that regard remain open.
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