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The oxygen level in air directs airway epithelial cell differentiation by controlling mitochondrial citrate export.
Sci Adv
January 2025
Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, USA.
Oxygen controls most metazoan metabolism, yet in mammals, tissue O levels vary widely. While extensive research has explored cellular responses to hypoxia, understanding how cells respond to physiologically high O levels remains uncertain. To address this problem, we investigated respiratory epithelia as their contact with air exposes them to some of the highest O levels in the body.
View Article and Find Full Text PDFClearing the Air on Pollutant Disruptions of the Gut-Brain Axis: Developmental Exposure to Benzo[a]pyrene Disturbs Zebrafish Behavior and the Gut Microbiome in Adults and Subsequent Generations.
Toxics
December 2024
Department of Microbiology, Oregon State University, Corvallis, OR 97333, USA.
Developmental exposure to benzo[a]pyrene (BaP), a ubiquitous environmental pollutant, has been linked to various toxic effects, including multigenerational behavioral impairment. While the specific mechanisms driving BaP neurotoxicity are not fully understood, recent work highlights two important determinants of developmental BaP neurotoxicity: (1) the aryl hydrocarbon receptor (AHR), which induces host metabolism of BaP, and (2) the gut microbiome, which may interact with BaP to affect its metabolism, or be perturbed by BaP to disrupt the gut-brain axis. We utilized the zebrafish model to explore the role of AHR, the gut microbiome, and their interaction, on BaP-induced neurotoxicity.
View Article and Find Full Text PDFTopological defects induced by air inclusions in ferroelectric nematic liquid crystals with ionic doping.
Soft Matter
January 2025
Department of Mechanical and Energy Engineering, Southern University of Science and Technology, Shenzhen, 518055, China.
We report an experimental study on how topological defects induced by cylindrical air inclusions in the ferroelectric nematic liquid crystal RM734 are influenced by ionic doping, including an ionic surfactant and ionic polymer. Our results show that subtle differences in molecular structure can lead to distinct surface alignments and topological defects. The ionic surfactant induces a planar alignment, with two -1/2 line defects adhering to the cylindrical bubble surface.
View Article and Find Full Text PDFOsteoclast visualization: Tartrate-resistant acid phosphatase activity staining using NewFuchsin compatible with non-aqueous mounting and tissue clearing.
MethodsX
June 2025
Laboratory of Cell and Tissue Biology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.
Tartrate-resistant acid phosphatase (TRAP) staining is widely used to stain osteoclasts in histological bone sections. The red dye formed by the conventional TRAP enzymatic reaction using naphthol AS-MX (or AS-BI) phosphate and fast red-violet (or garnet) chromogens is readily soluble in alcohol or xylene and requires air-drying prior to cover slipping or the use of an aqueous mounting medium. However, the use of an aqueous mounting medium makes it difficult to store stained specimens for a long time.
View Article and Find Full Text PDFA miniaturized RPA-CRISPR/Cas12a-based nucleic acid diagnostic platform for rapid and simple self-testing of SARS-CoV-2.
Anal Chim Acta
February 2025
State Key Laboratory for Manufacturing Systems Engineering, School of Instrument Science and Technology, Xi'an Jiaotong University, Xi'an, 710054, China.
Nucleic acid testing is the most effective detection method currently available for the diagnosis of respiratory infectious diseases. However, the conventional real-time fluorescent quantitative PCR technique, which is regarded as the gold standard method for nucleic acid detection, presents significant challenges for implementation in home self-testing and popularization in underdeveloped regions due to its rigorous experimental standards. It is therefore clear that an easy-to-use, miniaturized nucleic acid testing technology and products for nonprofessionals are of great necessity to define the pathogens and assist in controlling disease transmission.
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