AI Article Synopsis
- Researchers discovered 10 new insecticidal compounds, named endostemonines A-J, from an endophyte associated with a traditional Chinese medicine known for its insecticidal properties.
- These compounds are the first naturally occurring derivatives of pyrrole-2-carboxylic esters and contain various fatty acid chains attached to the pyrrole ring.
- All tested endostemonines showed strong lethal activity against pests, indicating potential for new, natural pesticide development from medicinal plants.
Article Abstract
The discovery of new, safe, and effective pesticides is one of the main means for modern crop protection and parasitic disease control. During the search for new insecticidal secondary metabolites from endophytes in (a traditional Chinese medicine with a long history as an insecticide), 10 new insecticidal endostemonines A-J () were identified from an endophytic sp. BS-1. Their structures were determined by comprehensive spectroscopic analysis. Endostemonines A-J represent the first reported naturally occurring pyrrole-2-carboxylic ester derivatives, which consisted of different fatty acid chains at the C-2 of pyrrole ring were produced by traditional Chinese medicine endophytic microbes. All new tested compounds exhibited strong lethal activity against (LC value range of 3.55-32.00 mg/L after 72 h). This research highlighted the discovery of pesticide natural products from insecticidal medicinal plant endophytes for the first time, paving a new pathway for the development of pest control.
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| http://dx.doi.org/10.1021/acs.jafc.9b06755 | DOI Listing |
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