Molecular switches in signaling networks as a mechanism of action for oncogenic mutations in proximity of tyrosine residues.

Mol Cell Oncol

Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Published: December 2019

We developed a mass spectrometry-based proteomics strategy to study oncogenic phosphotyrosine signaling networks in tissues. We outlined epidermal growth factor-dependent phosphotyrosine signaling in lung tissue and discovered that cancer mutations in vicinity of phosphotyrosine sites can induce molecular switches in recruited protein complexes, which ultimately alter the signaling outcome of the network activation.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6961691PMC
http://dx.doi.org/10.1080/23723556.2019.1692643DOI Listing

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