We developed a mass spectrometry-based proteomics strategy to study oncogenic phosphotyrosine signaling networks in tissues. We outlined epidermal growth factor-dependent phosphotyrosine signaling in lung tissue and discovered that cancer mutations in vicinity of phosphotyrosine sites can induce molecular switches in recruited protein complexes, which ultimately alter the signaling outcome of the network activation.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6961691 | PMC |
http://dx.doi.org/10.1080/23723556.2019.1692643 | DOI Listing |
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