AI Article Synopsis
- Breast tumors that are tough to treat with chemotherapy tend to have wild-type characteristics and enter a state called senescence after treatment.
- Senescence refers to a phase where cells stop dividing but remain alive, which contributes to the difficulty in fully eradicating these tumors.
- A key reason for the ongoing presence of these senescent cells is their acquisition of a new ability to consume other cells and materials, a process known as cannibalism.
Article Abstract
The breast tumors that are most difficult to eradicate with chemotherapy have wild-type and preferentially enter senescence after treatment. One factor contributing to the persistence of senescent cells in residual disease: acquisition of a novel phenotype that allows cannibalism of entire cells and engulfment of other substrates.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6961664 | PMC |
| http://dx.doi.org/10.1080/23723556.2019.1688601 | DOI Listing |
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