Introduction: Osteoarthritis knee is one of the most prevalent conditions of knee in elder age group of population. Its causes pain, disability in geriatric population of society. Longer life expectancy is responsible for increase in osteoarthritis knee. K-L scale is well known scale of radiographic OA knee. This study was done to find prevalence of OA knee in Indian population of older than 40 years using K-L scale.
Method: The study was a community based cross sectional study. The target population was from 5 metropolis, 5 cities near the metropolis, 5 towns and 20 villages from blocks of these towns. i.e. 5 sample groups were covered. Sample size n = 4680 which was further divided into 5 sites equally (936 from each site). This was rounded to a sample of 1000 from each site. This evaluation study was conducted using the household as the primary sampling unit for the quantitative survey. The respondents for the study were above 40 years. Quantitative data was collected using structured questionnaire and X-Ray Investigation. OA was graded using the Kellgren and Lawrence scale. Data analysis was performed using SPSS statistical software. Frequencies and percentages were calculated to find the prevalence of OA. Chi-Square test was used to find the association of OA with various factors.
Results: The present study shows a prevalence of 28.7% of OA in the overall sample. This varies slightly in the individual states - Agra (35.5%), Bangalore (26.6%), Kolkata (33.7%), Dehradun (27.2%), and Pune (21.7%).OA prevalence was found to be more in participants who used western toilet (42.1%), in sedentary people (82.9%), in females and in obese.
Conclusion: This study has evidenced that there is a large percentage of sub-threshold population. i.e. K-L grade 1 which is considered as border-line or doubt-full as far as OA diagnosis. Awareness of OA should be initiated at community level, which is needed for prevention of OA at early age.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6977151 | PMC |
http://dx.doi.org/10.1016/j.jcot.2019.05.019 | DOI Listing |
Bone Jt Open
January 2025
Department of Orthopaedic Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Aims: This study was performed to investigate the association between the acetabular morphology and the joint space narrowing rate (JSNR) in the non-arthritic hip.
Methods: We retrospectively reviewed standing whole-leg radiographs of patients who underwent knee arthroplasty from February 2012 to March 2020 at our institute. Patients with a history of hip surgery, Kellgren-Lawrence grade ≥ II hip osteoarthritis, or rheumatoid arthritis were excluded.
Clin Exp Rheumatol
January 2025
UMass Chan Medical School and UMass Memorial Medical Center, Boston, MA, USA.
Objectives: To assess the efficacy and safety of an intra-articular (IA) CLK/DYRK inhibitor, lorecivivint (LOR), for the treatment of moderate to severe symptomatic knee osteoarthritis (OA).
Methods: This was a Phase 3, 28-week, multicentre, double-blind, placebo-controlled study evaluating the efficacy and safety of a single IA injection of LOR. Patients with ACR-defined knee OA, Kellgren-Lawrence (KL) grades 2-3, and pain Numeric Rating Scale (NRS) ≥4 and ≤8 in the target knee were randomised (1:1) to receive LOR 0.
Clin Exp Rheumatol
January 2025
UMass Chan Medical School and UMass Memorial Medical Center, Boston, MA, USA.
Objectives: To determine the efficacy, safety, and tolerability of intraarticular (IA) lorecivivint (LOR) in the treatment of knee osteoarthritis (OA).
Methods: Patients with American College of Rheumatology criteria-defined knee OA, Kellgren-Lawrence (KL) grades 2-3, and medial Joint Space Width (JSW) by radiograph between 1.5 and 4 mm in the target knee were enrolled in this phase 3, 56-week, multicentre, double-blind, placebo-controlled study.
PM R
January 2025
Department of Physiatry, Hospital for Special Surgery, New York, New York, USA.
Background: Knee osteoarthritis (OA) and its impairments affect patients' physical and mental health. Radiographically severe knee OA is believed to respond less to conservative treatments including physical therapy (PT) but has not been compared specifically with Patient-Reported Outcomes Measurement Information System (PROMIS)-10.
Objective: To correlate baseline PROMIS-10 physical and mental health scores in patients undergoing PT for knee OA, subgrouped by radiographic severity (Kellgren-Lawrence [KL] grade and number of knee compartments involved).
J ISAKOS
January 2025
University of Virginia Health System, Department of Orthopaedic Surgery, Charlottesville, VA, USA.
Purpose: To update previously published clinical and radiographic outcomes of Dejour sulcus-deepening trochleoplasty and medial patellofemoral ligament reconstruction (MPFL-R), at mid-term follow-up, and monitor trends in patient reported outcome scores and satisfaction.
Methods: Using the same cohort of patients from our previously published short-term series of 2-year follow up, interval follow-up was performed on 67 patients (76 knees) with severe trochlear dysplasia and recurrent patellar instability who were prospectively enrolled and underwent Dejour sulcus-deepening trochleoplasty and MPFL-R combined with other patellar-stabilization procedures. Patients with less than 2-year follow-up were excluded.
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